Some Serum Cytokines in Celiac Disease, Non-Celiac
Keywords:
celiac Disease, Anti-tissue transglutaminase IL-2, IL(6) IFN γ
Abstract
Back ground and aims: In This study measuring the levels of some cytokines in Najaf patients with CD, NCGS and to compare with subjects.
Methods: This case control study was done to check the levels of markers in the serum of (60) patients the celiac disease (CD), NCGS (20) and who randomly recruited from different Hospital in Najaf Iraq during period between September 2022and January 2023 This was done using the ELISA method, age range of 40 healthy people were included this study with the same age and sex.
Results: the mean level of Interleukin -2(IL-2) high significant different between patients and healthy groups but (IL-6and IFN γ) no significant differences, Anti-tissue transglutaminase levels were showed significant correlation an with IL-2 cytokines.
Conclusion: IL-2 play role of pathology of celiac disease.
References
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25. Schoenborn, J. R., & Wilson, C. B. (2007). Regulation of interferon‐γ during innate and adaptive immune responses. Advances in immunology, 96, 41-101.
26. Nasserinejad, M., Shojaee, S., Ghobakhlou, M., Lak, E., Eslami, P., & Pourhoseingholi, M. A. (2019). The effects of IL-8, IL-6, and IL-1 on the risk of celiac disease: a Bayesian regression analysis. Gastroenterology and Hepatology from Bed to Bench, 12(Suppl1), S117.
27. Marafini, I., Monteleone, I., Di Fusco, D., Cupi, M. L., Paoluzi, O. A., Colantoni, A., Ortenzi, A., Izzo, R., Vita, S., & De Luca, E. (2015). TNF-α producing innate lymphoid cells (ILCs) are increased in active celiac disease and contribute to promote intestinal atrophy in mice. PLoS One, 10(5), e0126291.
28. Manavalan, J. S., Hernandez, L., Shah, J. G., Konikkara, J., Naiyer, A. J., Lee, A. R., ... & Bhagat, G. (2010). Serum cytokine elevations in celiac disease: association with disease presentation. Human immunology, 71(1), 50-57.
29. Sulkanen, S., Halttunen, T., Laurila, K., Kolho, K.-L., Korponay-Szabó, I. R., Sarnesto, A., Savilahti, E., Collin, P., & Mäki, M. (1998). Tissue
30. Bazzigaluppi, E., Lampasona, V., Barera, G., Venerando, A., Bianchi, C., Chiumello, G., Bonifacio, E., & Bosi, E. (1999). Comparison of tissue transglutaminase-specific antibody assays with established antibody measurements for coeliac disease. Journal of autoimmunity, 12(1), 51-56.
31. Abrams, J. A., Brar, P., Diamond, B., Rotterdam, H., & Green, P. H. (2006). Utility in clinical practice of immunoglobulin a anti-tissue transglutaminase antibody for the diagnosis of celiac disease. Clinical gastroenterology and hepatology, 4(6), 726-730.
32. Picarelli, A., Di Tola, M., Sabbatella, L., Mastracchio, A., Trecca, A., Gabrielli, F., Di Cello, T., Anania, M., & Torsoli, A. (2001). Identification of a new coeliac disease subgroup: antiendomysial and anti‐transglutaminase antibodies of IgG class in the absence of selective IgA deficiency. Journal of internal medicine, 249(2), 181-188.
2. Lebwohl, B., Sanders, D., & Green, P. (2018). Coeliac disease. Lancet391, 70–81. In.
3. Fasano, A., & Catassi, C. (2012). Celiac disease. New England Journal of Medicine, 367(25), 2419-2426.
4. Poddighe, D., & Abdukhakimova, D. (2021). Celiac Disease in Asia beyond the Middle East and Indian subcontinent: Epidemiological burden and diagnostic barriers. World journal of gastroenterology, 27(19), 2251.
5. Whitburn, J., Rao, S. R., Paul, S. P., & Sandhu, B. K. (2021). Diagnosis of celiac disease is being missed in over 80% of children particularly in those from socioeconomically deprived backgrounds. European Journal of Pediatrics, 180, 1941-1946.
6. Verdu, E. F., Armstrong, D., & Murray, J. A. (2009). Between celiac disease and irritable bowel syndrome: the “no man’s land” of gluten sensitivity. The American journal of gastroenterology, 104(6), 1587
7. Carroccio, A., Mansueto, P., Iacono, G., Soresi, M., D'alcamo, A., Cavataio, F., Brusca, I., Florena, A. M., Ambrosiano, G., & Seidita, A. (2012). Non-celiac wheat sensitivity diagnosed by double-blind placebo-controlled challenge: exploring a new clinical entity. Official journal of the American College of Gastroenterology| ACG, 107(12), 1898-1906.
8. Catassi, C., Elli, L., Bonaz, B., Bouma, G., Carroccio, A., Castillejo, G., Cellier, C., Cristofori, F., De Magistris, L., & Dolinsek, J. (2015). Diagnosis of non-celiac gluten sensitivity (NCGS): the Salerno experts’ criteria. Nutrients, 7(6), 4966-4977.
9. Rostami, K., & Hogg-Kollars, S. (2012). Non-coeliac gluten sensitivity: a patient’s journey. BMJ, 345, e7982.
10. Ontiveros, N., López-Gallardo, J. A., Vergara-Jiménez, M. J., & Cabrera-Chávez, F. (2015). Self-reported prevalence of symptomatic adverse reactions to gluten and adherence to gluten-free diet in an adult Mexican population. Nutrients, 7(7), 6000-6015.
11. Ylönen, V., Lindfors, K., Repo, M., Huhtala, H., Fuchs, V., Saavalainen, P., Musikka, A., Laurila, K., Kaukinen, K., & Kurppa, K. (2020). Non-biopsy serology-based diagnosis of celiac disease in adults is accurate with different commercial kits and pre-test probabilities. Nutrients, 12(9), 2736.
12. Goel, G., Tye-Din, J. A., Qiao, S.-W., Russell, A. K., Mayassi, T., Ciszewski, C., Sarna, V. K., Wang, S., Goldstein, K. E., & Dzuris, J. L. (2019). Cytokine release and gastrointestinal symptoms after gluten challenge in celiac disease. Science advances, 5(8), eaaw7756.
13. Mazzarella, G. (2015). Effector and suppressor T cells in celiac disease. World Journal of Gastroenterology: WJG, 21(24), 7349.
14. Iversen, R., Amundsen, S. F., Kleppa, L., du Pré, M. F., Stamnaes, J., & Sollid, L. M. (2020). Evidence that pathogenic transglutaminase 2 in celiac disease derives from enterocytes. Gastroenterology, 159(2), 788-790.
15. Romaldini, C. C., Barbieri, D., Okay, T. S., Raiz Jr, R., & Cançado, E. L. (2002). Serum soluble interleukin-2 receptor, interleukin-6, and tumor necrosis factor-α levels in children with celiac disease: response to treatment. Journal of pediatric gastroenterology and nutrition, 35(4), 513-517.
16. Crespo-Escobar, P., Mearin, M. L., Hervas, D., Auricchio, R., Castillejo, G., Gyimesi, J., Martinez-Ojinaga, E., Werkstetter, K., Vriezinga, S. L., & Korponay-Szabo, I. R. (2017). The role of gluten consumption at an early age in celiac disease development: a further analysis of the prospective PreventCD cohort study. The American journal of clinical nutrition, 105(4), 890-896.
17. Heydari, F., Rostami-Nejad, M., Moheb-Alian, A., Mollahoseini, M. H., Rostami, K., Pourhoseingholi, M. A., Aghamohammadi, E., & Zali, M. R. (2018). Serum cytokines profile in treated celiac disease compared with non-celiac gluten sensitivity and control: a marker for differentiation. Journal of Gastrointestinal & Liver Diseases, 27(3).
18. Tanpowpong, P., Ingham, T. R., Lampshire, P. K., Kirchberg, F. F., Epton, M. J., Crane, J., & Camargo, C. A. (2012). Coeliac disease and gluten avoidance in New Zealand children. Archives of Disease in Childhood, 97(1), 12-16.
19. Heydari, F., Rostami-Nejad, M., Moheb-Alian, A., Mollahoseini, M. H., Rostami, K., Pourhoseingholi, M. A., Aghamohammadi, E., & Zali, M. R. (2018). Serum cytokines profile in treated celiac disease compared with non-celiac gluten sensitivity and control: a marker for differentiation. Journal of Gastrointestinal & Liver Diseases, 27(3).
20. Binicier, O. B., & Tosun, F. (2020). Evaluation of adult celiac disease from a tertiary reference center: a retrospective analysis. Revista da Associação Médica Brasileira, 66, 55-60
21. Sbarbati, A., Valletta, E., Bertini, M., Cipolli, M., Morroni, M., Pinelli, L., & Tatò, L. (2003). Gluten sensitivity and ‘normal’histology: is the intestinal mucosa really normal? Digestive and Liver Disease, 35(11), 768-773.
22. Goel, G., Tye-Din, J. A., Qiao, S.-W., Russell, A. K., Mayassi, T., Ciszewski, C., Sarna, V. K., Wang, S., Goldstein, K. E., & Dzuris, J. L. (2019). Cytokine release and gastrointestinal symptoms after gluten challenge in celiac disease. Science advances, 5(8), eaaw7756.
23. Anderson, R. P., Henry, M. J., Taylor, R., Duncan, E. L., Danoy, P., Costa, M. J., Addison, K., Tye-Din, J. A., Kotowicz, M. A., & Knight, R. E. (2013). A novel serogenetic approach determines the community prevalence of celiac disease and informs improved diagnostic pathways. BMC medicine, 11, 1-13.
24. Nenna, R., Petrarca, L., Verdecchia, P., Florio, M., Pietropaoli, N., Mastrogiorgio, G., ... & Cucchiara, S. (2016). Celiac disease in a large cohort of children and adolescents with recurrent headache: a retrospective study. Digestive and Liver Disease, 48(5), 495-498.
25. Schoenborn, J. R., & Wilson, C. B. (2007). Regulation of interferon‐γ during innate and adaptive immune responses. Advances in immunology, 96, 41-101.
26. Nasserinejad, M., Shojaee, S., Ghobakhlou, M., Lak, E., Eslami, P., & Pourhoseingholi, M. A. (2019). The effects of IL-8, IL-6, and IL-1 on the risk of celiac disease: a Bayesian regression analysis. Gastroenterology and Hepatology from Bed to Bench, 12(Suppl1), S117.
27. Marafini, I., Monteleone, I., Di Fusco, D., Cupi, M. L., Paoluzi, O. A., Colantoni, A., Ortenzi, A., Izzo, R., Vita, S., & De Luca, E. (2015). TNF-α producing innate lymphoid cells (ILCs) are increased in active celiac disease and contribute to promote intestinal atrophy in mice. PLoS One, 10(5), e0126291.
28. Manavalan, J. S., Hernandez, L., Shah, J. G., Konikkara, J., Naiyer, A. J., Lee, A. R., ... & Bhagat, G. (2010). Serum cytokine elevations in celiac disease: association with disease presentation. Human immunology, 71(1), 50-57.
29. Sulkanen, S., Halttunen, T., Laurila, K., Kolho, K.-L., Korponay-Szabó, I. R., Sarnesto, A., Savilahti, E., Collin, P., & Mäki, M. (1998). Tissue
30. Bazzigaluppi, E., Lampasona, V., Barera, G., Venerando, A., Bianchi, C., Chiumello, G., Bonifacio, E., & Bosi, E. (1999). Comparison of tissue transglutaminase-specific antibody assays with established antibody measurements for coeliac disease. Journal of autoimmunity, 12(1), 51-56.
31. Abrams, J. A., Brar, P., Diamond, B., Rotterdam, H., & Green, P. H. (2006). Utility in clinical practice of immunoglobulin a anti-tissue transglutaminase antibody for the diagnosis of celiac disease. Clinical gastroenterology and hepatology, 4(6), 726-730.
32. Picarelli, A., Di Tola, M., Sabbatella, L., Mastracchio, A., Trecca, A., Gabrielli, F., Di Cello, T., Anania, M., & Torsoli, A. (2001). Identification of a new coeliac disease subgroup: antiendomysial and anti‐transglutaminase antibodies of IgG class in the absence of selective IgA deficiency. Journal of internal medicine, 249(2), 181-188.
Published
2023-08-05
How to Cite
Abd, A. A., & Hamad, D. W. S. (2023). Some Serum Cytokines in Celiac Disease, Non-Celiac. Central Asian Journal of Medical and Natural Science, 4(4), 247-256. Retrieved from https://cajmns.centralasianstudies.org/index.php/CAJMNS/article/view/1694
Section
Articles
