Synthesis, Characterization and Biological Activity Evaluation of Some New Pyrimidine Derivatives by Solid Base Catalyst AL2O3-OBa
Keywords:
Chalcones, Solid base catalyst, AL2O3, Pyrimidine, Biological activity
Abstract
This work involve the preparation and characterization of new derivatives of pyrimidine compounds from the reaction of chalcones with Urea via solid base catalyst (prepared through the reaction of Ba(NO3)2 with AL2O3 at (300-700) °C to obtain metal oxide as a solid base catalyst) and using physical methods. And spectroscopic (melting point, color, product ratio, IR, 1H-NMR, and 13C-NMR), the compositions were confirmed to be correct. The antibacterial activity has been tested in vitro by the disk diffusion assay method against two kinds of bacteria gram positive and gram negative. The minimum inhibitory concentration [MIC] have been determined with the reference of stander drugs, the results showed that the Pyrazoline derivatives are better than growth of both types of bacteria (gram- positive and germ–negative) compared to drug.
References
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23. Aftan, M. M., Talloh, A. A., Dalaf, A. H., & Salih, H. K. (2021). Impact para position on rho value and rate constant and study of liquid crystalline behavior of azo compounds. Materials Today: Proceedings, 45, 5529-5534.
24. Dalaf, A. H., & Jumaa, F. H. (2020). Synthesis, Identification and Assess the Biological and Laser Efficacy of New Compounds of Azetidine Derived from Benzidine. Muthanna Journal of Pure Science (MJPS), 7(2):12-25
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27. Kovalova, M., Havlíček, L., Djukic, S., Škerlová, J., Peřina, M., Pospíšil, T., ... & Kryštof, V. (2023). Characterization of new highly selective pyrazolo [4, 3-d] pyrimidine inhibitor of CDK7. Biomedicine & Pharmacotherapy, 161, 114492.
28. Mohamed, S. A., Al-Badrany, K. A., & Huseen, M. S. (2022). PREPARATION AND STUDY OF BIOLOGICAL ACTIVITY OF PYRIMIDINE COMPOUNDS DERIVED FROM 2-ACETYLPYRIDINE. Vegueta. Anuario de la Facultad de Geografía e Historia, 22, 8.
29. Al-Hadidi, O. A. F., Al-Badrany, K. A., & Al-Bajari, S. A. (2022). Synthesis some of thiazepine compounds from 2-carbboxyaldehyde-5-methyl thiophene and study their biological activity on infected male rats epileptic. Journal of Education and Scientific Studies, 2(20).
30. Al-Tufah, M. M., Jasim, S. S., & Al-Badrany, K. A. (2020). Synthesis and Antibacterial Evaluation of some New Pyrazole Derivatives. Prof.(Dr) RK Sharma, 20(3), 178.
31. Khalid, A., Ahmed, A. A., & Wissam, M. R. (2022). Synthesis and characterization of some azetidine Derivatives that derived from 6-Bromo-4-Fluoro-2-Aminobenzothiazole and Study Their biological activity. Journal of Education and Scientific Studies, 2(20).
2. Joule, J. A. (2020). Heterocyclic chemistry. CRC Press.
3. Ahamed, A., Arif, I. A., SurendraKumar, R., Akbar, I., & Shaik, B. (2023). Antimicrobial and cytotoxic activities of novel pyrimidine-2, 4-dione connected with 2H-thiopyran derivatives. Journal of King Saud University-Science, 35(4), 102588.
4. Wang, T., Wu, F., Luo, L., Zhang, Y., Ma, J., & Hu, Y. (2022). Efficient synthesis and cytotoxic activity of polysubstituted thieno [2, 3-d] pyrimidine derivatives. Journal of Molecular Structure, 1256, 132497.
5. Rani, N. V., & Kunta, R. (2021). PEG-400 promoted a simple, efficient and eco-friendly synthesis of functionalized novel isoxazolyl pyrido [2, 3-d] pyrimidines and their antimicrobial and anti-inflammatory activity. Synthetic Communications, 51(8), 1171-1183.
6. Radwan, M. A., Alshubramy, M. A., Abdel-Motaal, M., Hemdan, B. A., & El-Kady, D. S. (2020). Synthesis, molecular docking and antimicrobial activity of new fused pyrimidine and pyridine derivatives. Bioorganic Chemistry, 96, 103516.
7. El-Sayed, E. H., & Mohamed, K. S. (2021). Synthesis and anti-inflammatory evaluation of some new pyrazole, pyrimidine, pyrazolo [1, 5-a] pyrimidine, imidazo [1, 2-b] pyrazole and pyrazolo [5, 1-b] quinazoline derivatives containing indane moiety. Polycyclic Aromatic Compounds, 41(5), 1077-1093.
8. Wang, H., Cui, E., Li, J., Ma, X., Jiang, X., Du, S., ... & Du, L. (2022). Design and synthesis of novel indole and indazole-piperazine pyrimidine derivatives with anti-inflammatory and neuroprotective activities for ischemic stroke treatment. European Journal of Medicinal Chemistry, 241, 114597.
9. Gajjala, R. R., Chinta, R. R., Gopireddy, V. S. R., Poola, S., Balam, S. K., Chintha, V., ... & Cirandur, S. R. (2022). Ethyl-4-(aryl)-6-methyl-2-(oxo/thio)-3, 4-dihydro-1H-pyrimidine-5-carboxylates: Silica supported bismuth (III) triflate catalyzed synthesis and antioxidant activity. Bioorganic Chemistry, 129, 106205.
10. Mohire, P. P., Chandam, D. R., Patravale, A. A., Choudhari, P., Karande, V., Ghosh, J. S., & Deshmukh, M. B. (2021). An expedient four component synthesis of substituted pyrido-pyrimidine heterocycles in glycerol: proline based low transition temperature mixture and their antioxidant activity with molecular docking studies. Polycyclic Aromatic Compounds, 42(1), 137-155.
11. Ahmadi, N., Sayyed-Alangi, S. Z., & Varasteh-Moradi, A. (2022). Cu@ KF/Clinoptilolite Nanoparticles Promoted Green Synthesis of Pyrimidine Derivatives: Study of Antioxidant Activity. Polycyclic Aromatic Compounds, 42(7), 4019-4033.
12. Dastmard, S., Mamaghani, M., Farahnak, L., & Rassa, M. (2022). Facile Synthesis of Polyfunctional Indole-Pyrido [2, 3-d] Pyrimidine Hybrids Using Nickel-Incorporated Fluorapatite Encapsulated Iron Oxide Nanocatalyst and Study of Their Antibacterial Activities. Polycyclic Aromatic Compounds, 42(4), 1747-1760.
13. Ding, R., Wang, X., Fu, J., Chang, Y., Li, Y., Liu, Y., ... & Hu, J. (2022). Design, synthesis and antibacterial activity of novel pleuromutilin derivatives with thieno [2, 3-d] pyrimidine substitution. European Journal of Medicinal Chemistry, 237, 114398.
14. Dai, X. J., Xue, L. P., Ji, S. K., Zhou, Y., Gao, Y., Zheng, Y. C., ... & Liu, H. M. (2023). Triazole-fused pyrimidines in target-based anticancer drug discovery. European Journal of Medicinal Chemistry, 115101.
15. Albratty, M., & Alhazmi, H. A. (2022). Novel pyridine and pyrimidine derivatives as promising anticancer agents: A review. Arabian Journal of Chemistry, 103846.
16. Ono, Y. (2003). Solid base catalysts for the synthesis of fine chemicals. Journal of Catalysis, 216(1-2), 406-415.
17. Liu, X., He, H., Wang, Y., & Zhu, S. (2007). Transesterification of soybean oil to biodiesel using SrO as a solid base catalyst. Catalysis Communications, 8(7), 1107-1111.
18. Su, F., Antonietti, M., & Wang, X. (2012). mpg-C 3 N 4 as a solid base catalyst for Knoevenagel condensations and transesterification reactions. Catalysis Science & Technology, 2(5), 1005-1009
19. Al-Joboury, W. M., Al-Badrany, K. A., & Asli, N. J. (2022, November). N-alkylation of substituted 2-amino benzothiazoles by 1, 4-bis (bromo methyl) benzene on mixed oxides at room temperature and study their biological activity. In AIP Conference Proceedings (Vol. 2394, No. 1, p. 040054). AIP Publishing LLC..
20. Salih, B. D., Dalaf, A. H., Alheety, M. A., Rashed, W. M., & Abdullah, I. Q. (2021). Biological activity and laser efficacy of new Co (II), Ni (II), Cu (II), Mn (II) and Zn (II) complexes with phthalic anhydride. Materials Today: Proceedings, 43, 869-874.
21. Aftan, M. M., Jabbar, M. Q., Dalaf, A. H., & Salih, H. K. (2021). Application of biological activity of oxazepine and 2-azetidinone compounds and study of their liquid crystalline behavior. Materials Today: Proceedings, 43, 2040-2050.
22. Dalaf, A. H. (2018). Synthesis and Characterization of Some Quartet and Quinary Hetero cyclic Rings Compounds by Traditional Method and Microwave Routes Method and Evaluation of Their Biological Activity. M.Sc. Thesis, Tikrit University, Tikrit, Iraq: 1-94 pp.
23. Aftan, M. M., Talloh, A. A., Dalaf, A. H., & Salih, H. K. (2021). Impact para position on rho value and rate constant and study of liquid crystalline behavior of azo compounds. Materials Today: Proceedings, 45, 5529-5534.
24. Dalaf, A. H., & Jumaa, F. H. (2020). Synthesis, Identification and Assess the Biological and Laser Efficacy of New Compounds of Azetidine Derived from Benzidine. Muthanna Journal of Pure Science (MJPS), 7(2):12-25
25. Reimer, L. (2000). Scanning electron microscopy: physics of image formation and microanalysis. Measurement Science and Technology, 11(12), 1826-1826.
26. Ejaz, S. A., Zain-ul-Abideen, M., Channar, P. A., Saeed, A., Ahmed, A., Alsaiari, N. S., ... & Mustafa, M. N. (2023). Synthesis, biochemical characterization and molecular modeling studies of 5-(substituted benzylidene) pyrimidine-2, 4, 6-trione: Potential inhibitors of alkaline phosphatase. Journal of Molecular Structure, 1282, 135225.
27. Kovalova, M., Havlíček, L., Djukic, S., Škerlová, J., Peřina, M., Pospíšil, T., ... & Kryštof, V. (2023). Characterization of new highly selective pyrazolo [4, 3-d] pyrimidine inhibitor of CDK7. Biomedicine & Pharmacotherapy, 161, 114492.
28. Mohamed, S. A., Al-Badrany, K. A., & Huseen, M. S. (2022). PREPARATION AND STUDY OF BIOLOGICAL ACTIVITY OF PYRIMIDINE COMPOUNDS DERIVED FROM 2-ACETYLPYRIDINE. Vegueta. Anuario de la Facultad de Geografía e Historia, 22, 8.
29. Al-Hadidi, O. A. F., Al-Badrany, K. A., & Al-Bajari, S. A. (2022). Synthesis some of thiazepine compounds from 2-carbboxyaldehyde-5-methyl thiophene and study their biological activity on infected male rats epileptic. Journal of Education and Scientific Studies, 2(20).
30. Al-Tufah, M. M., Jasim, S. S., & Al-Badrany, K. A. (2020). Synthesis and Antibacterial Evaluation of some New Pyrazole Derivatives. Prof.(Dr) RK Sharma, 20(3), 178.
31. Khalid, A., Ahmed, A. A., & Wissam, M. R. (2022). Synthesis and characterization of some azetidine Derivatives that derived from 6-Bromo-4-Fluoro-2-Aminobenzothiazole and Study Their biological activity. Journal of Education and Scientific Studies, 2(20).
Published
2023-08-05
How to Cite
Saleh, J. N., & Al-Badrany, K. A. (2023). Synthesis, Characterization and Biological Activity Evaluation of Some New Pyrimidine Derivatives by Solid Base Catalyst AL2O3-OBa. Central Asian Journal of Medical and Natural Science, 4(4), 231-239. Retrieved from https://cajmns.centralasianstudies.org/index.php/CAJMNS/article/view/1692
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