Gc-Ms Analysis of the Chemical Composition of Essential Oil Isolated From Achillea Millefolium L.
Keywords:
Achillea millefolium L., essential oil, GC-MS, chemical composition, monoterpenes, sesquiterpenes, phenols, oxides.
Abstract
This article focuses on analyzing the chemical composition of the essential oil extracted from Achillea millefolium L. The GC-MS method was employed to identify a total of 34 compounds, which were categorized into various classes such as monoterpenes, sesquiterpenes, oxygenated monoterpenes, and oxygenated sesquiterpenes. The two most abundant components found in the oil were 2-karen and ascaridole. Monoterpenes were found in a large number and were the predominant class of compounds in the essential oil. The findings of this study have potential implications in the development of new medicines and natural products. Moreover, exploring the chemical composition of Achillea millefolium L. essential oil could serve as a starting point for further research in the field of herbal medicine and phytotherapy.
References
1. Ali, S. I., Gopalakrishnan, B., Venkatesalu, V. (2017). Pharmacognosy, phytochemistry and pharmacological properties of Achillea millefolium L.: A review. Phytotherapy Research, 31(8), 1140-1161. https://doi.org/10.1002/ptr.5840.
2. Al-Snafi, A. E. (2013). Chemical constituents and pharmacological activities of milfoil (Achillea santolina)-a review. International Journal of Pharmacy and Technology Research, 5(3), 1373-1377.
3. Istamkulova, M. M., Mukhamadiev, N. K., Makhmudova, G. N. (2022). GC-MS study of the composition of essential oil Achillea millefolium L. Abu Ali Ibn Sino and innovations in modern pharmaceuticals. Collection of the V International Scientific and Practical Conference, 121-122.
4. Mazova, O. V., Apykhtin, N. N., & Plemenkov, V. V. (2009). Chemotaxonomy of the common yarrow (Achillea millefolium l). Chemistry of Plant Materials , (3), 85-88.
5. Vernikovskaya, N. A., & Temerdashev, Z. A. (2012). Identification and chromatographic determination of phenolic compounds in common yarrow. Analytics and control. 2012. No. 2 , 188-195.
6. Kerimli, E. G. O., Gasimov, E. K. O., Serkerov, S. V. O., Karimov, Yu. B. O., Rzaev, F. G. O., Muradova, S. A K., & Israfilova, S. A. K. (2021). Studying the composition of Achillea Nobilis L. essential oil and its antibacterial effect on changes in staphylococcus aureus cell ultrastructure. Chemistry of Plant Materials , (1), 93-104. https://doi.org/10.14258/jcprm.2021017446.
7. Roloff, J., Skagen, E. B., Steen, A. H., Iversen, T. H. (2000). Production of yarrow (Achillea millefolium L.) in Norway: Essential oil content and quality. Journal of Agricultural and Food Chemistry, 48(12), 6205-6209. https://doi.org/10.1021/jf000720p
8. Orav, A., Kailas, T., Ivask, K. (2001). Composition of essential oil from Achillea millefolium L. from Estonia. Journal of Research of Essential Oils, 13(4), 290-294. https://doi.org/10.1080/10412905.2001.9699697
9. Nadim, M. M., Malik, A. A., Ahmad, J., Bakshi, S. K. (2011). Composition of Achillea millefolium L. essential oil cultivated in tropical conditions of India. World Agricultural Science, 7(5), 561-565.
10. Smeltserovich, A., Lamshoft, M., Radulovich, N., Ilich, D., Palich, R. (2010). LCD–MS analysis of essential oils of Achillea millefolium and Achillea crithmifolia. Chromatography, 71, 113-116. https://doi.org/10.1365/s10337-009-1393-4.
11. Shawl, A. S., Srivastava, S. K., Syamasundar, K. V., Tripathi, S., & Raina, V. K. (2002). Essential oil composition of Achillea millefolium L. growing wild in Kashmir, India. Flavour and fragrance journal, 17(3), 165-168. https://doi.org/10.1002/ffj.1074.
12. Nazir, I., Gangu, S. A., Sophie, P. A., & Singh, A. (2022). GC-MS analysis and antioxidant activity of essential oil from Achillea millefolium L. flowers in temperate climatic conditions of Kashmir. Journal of Essential Oil Plants, 25(2), 290-296. https://doi.org/10.1080/0972060X.2022.2083456
13. Mockute, D., & Judzentiene, A. (2003). Variability of the essential oils composition of Achillea millefolium ssp. millefolium growing wild in Lithuania. Biochemical Systematics and Ecology, 31(9), 1033-1045. https://doi.org/10.1016/S0305-1978(03)000668.
14. Tuberoso, K. I. G., & Kovalchik, A. (2009). Chemical composition of Achillea millefolium L. essential oils isolated by various distillation methods. Journal of Research of Essential Oils, 21(2), 108-111. http://dx.doi.org/10.22092/ijmapr.2014.9833.
15. Farhadi, N., Babai, K., Farsarai, S., Moghaddam, M., & Pirbaluti, A. G. (2020). Changes in the composition of essential oils, the total content of phenol, flavonoids and the antioxidant capacity of Achillea millefolium at different stages of growth. Technical Cultures and Products, 152, 112570. https://doi.org/10.1016/j.indcrop.2020.112570.
16. Zorikov, P. S., & Anisimov, M. M. (2013). Essential oil plants of the families Apiaceae, Asteraceae and Lamiaceae in the North-West of Russia (biological features, composition and prospects for the use of essential oils).
17. Kazemi, M. (2015). Chemical composition and antimicrobial, antioxidant activity and anti-inflammatory potential of essential oils Achillea millefolium L., Anethum graveolens L., and Carum copticum L. Journal of Phytotherapy, 5(4), 217-222. https://doi.org/10.1016/j.hermed.2015.09001.
18. Istamkulova, M. M., Mukhamadiev, N. K., Keldiyarov, O. H., & Makhmudova, G. N. (2023). Analysis of the chemical composition of essential oil extracted from Achillea millefolium L. by GC-MS method. In Proceedings of the International Scientific and Practical Conference "Modern Achievements in Biomedicine and Ecology" dedicated to the 70th anniversary of the Doctor of Biological Sciences, Professor Shalakhmetova T. M. (April 20, 2023) (pp. 74-76).
19. Benedek, B., Rothwangl-Wiltschnigg, K., Rozema, E., et al. (2008). Yarrow (Achillea millefolium L. sl): Pharmaceutical quality of commercial samples. Die Pharmazie-An International Journal of Pharmaceutical Sciences, 63(1), 23-26. https://doi.org/10.1691/ph.2008.7646
20. Kurchenko, V. P., Sushinskaya, N. V., Chubarova, A. S., Tarun, E. I., Kupriyanov, A. N., Khrustaleva, I. A., ... & Shabunya, P. G. (2019). The composition of biologically active substances of extracts of yarrow flowers of the native flora of Belarus, Kazakhstan and Russia, their antioxidant properties and toxicity. Ecobiotech , 2 (3), 286-292. https://doi.org/10.31163/2618-964X-2019-2-3-286-292
21. Jatdoeva, D. T. (2022). Studying the composition of medicinal plants in the prevention of infectious diseases based on biochemical mechanisms. Bulletin of the Kursk State Agricultural Academy , (9), 88-93.
22. Candan, F., Unlu, M., Tepe, B., Daferera, D., Polissiou, M., Sökmen, A., & Akpulat, H. A. (2003). Antioxidant and antimicrobial activity of the essential oil and methanol extracts of Achillea millefolium subsp. millefolium Afan.(Asteraceae). Journal of ethnopharmacology, 87(2-3), 215-220. https://doi.org/10.1016/S0378-8741(03)00149-1
23. El-Kalamouni, S., Venskutonis, P. R., Zebib, B., Mera, O., Reynaud, S., & Talu, T. (2017). Antioxidant and antimicrobial activity of Achillea millefolium L. essential oil grown in France. Medicinal Products, 4(2), 30. https://doi.org/10.3390/medicines4020030.
24. Mazandarani, M., Mirdeylami, S. Z., & Pessarakli, M. (2013). Composition of essential oil and antibacterial activity of Achillea millefolium L. from different regions of northeastern Iran. Journal of Medicinal Plant Research, 7(16), 1063-1069. https://doi.org/10.5897/JMPR12.961.
25. Santoro, G. F., Cardoso, M. G., Guimar alzes, L. G. L., Mendon minnesa, L. Z., & Soares, M. J. (2007). Trypanosoma cruzi: Activity of essential oils from Achillea millefolium L., Syzygium aromaticum L. and Ocimum basilicum L. on epimastigotes and trypomastigotes. Experimental Parasitology, 116(3), 283-290. https://doi.org/10.1016/j.exppara.2007.01018.
26. Howyzeh, M. S., Aslani, S., & Pooraskari, O. (2019). Essential oil profile of an Iranian yarrow (Achillea millefolium). Journal of Essential Oil Bearing Plants, 22(1), 295-300. https://doi.org/10.1080/0972060X.2019.1586589
27. Stoletov, Yu. V., & Ulanova, V. A. (2020). The use of common yarrow (Achillea millefólium L.) in folk and official medicine, the prospects for its use. https://doi.org/10.36074/18.09.2020.v2.26
28. Akhmetyanov, R. T., Khasanova, Z. M., & Khasanova, L. A. (2019). Yarrow (Achillea millefolium L.) as a basis for functional products. Bulletin of the Bashkir State Pedagogical University. M. Akmulla , (1 (49)), 6-11.
29. Chusovitina, K. A., & Karpukhin, M. Yu. (2019). Pharmacological features of common yarrow (Achillea millefolium L.). Agricultural Education and Science , (4), 31.
2. Al-Snafi, A. E. (2013). Chemical constituents and pharmacological activities of milfoil (Achillea santolina)-a review. International Journal of Pharmacy and Technology Research, 5(3), 1373-1377.
3. Istamkulova, M. M., Mukhamadiev, N. K., Makhmudova, G. N. (2022). GC-MS study of the composition of essential oil Achillea millefolium L. Abu Ali Ibn Sino and innovations in modern pharmaceuticals. Collection of the V International Scientific and Practical Conference, 121-122.
4. Mazova, O. V., Apykhtin, N. N., & Plemenkov, V. V. (2009). Chemotaxonomy of the common yarrow (Achillea millefolium l). Chemistry of Plant Materials , (3), 85-88.
5. Vernikovskaya, N. A., & Temerdashev, Z. A. (2012). Identification and chromatographic determination of phenolic compounds in common yarrow. Analytics and control. 2012. No. 2 , 188-195.
6. Kerimli, E. G. O., Gasimov, E. K. O., Serkerov, S. V. O., Karimov, Yu. B. O., Rzaev, F. G. O., Muradova, S. A K., & Israfilova, S. A. K. (2021). Studying the composition of Achillea Nobilis L. essential oil and its antibacterial effect on changes in staphylococcus aureus cell ultrastructure. Chemistry of Plant Materials , (1), 93-104. https://doi.org/10.14258/jcprm.2021017446.
7. Roloff, J., Skagen, E. B., Steen, A. H., Iversen, T. H. (2000). Production of yarrow (Achillea millefolium L.) in Norway: Essential oil content and quality. Journal of Agricultural and Food Chemistry, 48(12), 6205-6209. https://doi.org/10.1021/jf000720p
8. Orav, A., Kailas, T., Ivask, K. (2001). Composition of essential oil from Achillea millefolium L. from Estonia. Journal of Research of Essential Oils, 13(4), 290-294. https://doi.org/10.1080/10412905.2001.9699697
9. Nadim, M. M., Malik, A. A., Ahmad, J., Bakshi, S. K. (2011). Composition of Achillea millefolium L. essential oil cultivated in tropical conditions of India. World Agricultural Science, 7(5), 561-565.
10. Smeltserovich, A., Lamshoft, M., Radulovich, N., Ilich, D., Palich, R. (2010). LCD–MS analysis of essential oils of Achillea millefolium and Achillea crithmifolia. Chromatography, 71, 113-116. https://doi.org/10.1365/s10337-009-1393-4.
11. Shawl, A. S., Srivastava, S. K., Syamasundar, K. V., Tripathi, S., & Raina, V. K. (2002). Essential oil composition of Achillea millefolium L. growing wild in Kashmir, India. Flavour and fragrance journal, 17(3), 165-168. https://doi.org/10.1002/ffj.1074.
12. Nazir, I., Gangu, S. A., Sophie, P. A., & Singh, A. (2022). GC-MS analysis and antioxidant activity of essential oil from Achillea millefolium L. flowers in temperate climatic conditions of Kashmir. Journal of Essential Oil Plants, 25(2), 290-296. https://doi.org/10.1080/0972060X.2022.2083456
13. Mockute, D., & Judzentiene, A. (2003). Variability of the essential oils composition of Achillea millefolium ssp. millefolium growing wild in Lithuania. Biochemical Systematics and Ecology, 31(9), 1033-1045. https://doi.org/10.1016/S0305-1978(03)000668.
14. Tuberoso, K. I. G., & Kovalchik, A. (2009). Chemical composition of Achillea millefolium L. essential oils isolated by various distillation methods. Journal of Research of Essential Oils, 21(2), 108-111. http://dx.doi.org/10.22092/ijmapr.2014.9833.
15. Farhadi, N., Babai, K., Farsarai, S., Moghaddam, M., & Pirbaluti, A. G. (2020). Changes in the composition of essential oils, the total content of phenol, flavonoids and the antioxidant capacity of Achillea millefolium at different stages of growth. Technical Cultures and Products, 152, 112570. https://doi.org/10.1016/j.indcrop.2020.112570.
16. Zorikov, P. S., & Anisimov, M. M. (2013). Essential oil plants of the families Apiaceae, Asteraceae and Lamiaceae in the North-West of Russia (biological features, composition and prospects for the use of essential oils).
17. Kazemi, M. (2015). Chemical composition and antimicrobial, antioxidant activity and anti-inflammatory potential of essential oils Achillea millefolium L., Anethum graveolens L., and Carum copticum L. Journal of Phytotherapy, 5(4), 217-222. https://doi.org/10.1016/j.hermed.2015.09001.
18. Istamkulova, M. M., Mukhamadiev, N. K., Keldiyarov, O. H., & Makhmudova, G. N. (2023). Analysis of the chemical composition of essential oil extracted from Achillea millefolium L. by GC-MS method. In Proceedings of the International Scientific and Practical Conference "Modern Achievements in Biomedicine and Ecology" dedicated to the 70th anniversary of the Doctor of Biological Sciences, Professor Shalakhmetova T. M. (April 20, 2023) (pp. 74-76).
19. Benedek, B., Rothwangl-Wiltschnigg, K., Rozema, E., et al. (2008). Yarrow (Achillea millefolium L. sl): Pharmaceutical quality of commercial samples. Die Pharmazie-An International Journal of Pharmaceutical Sciences, 63(1), 23-26. https://doi.org/10.1691/ph.2008.7646
20. Kurchenko, V. P., Sushinskaya, N. V., Chubarova, A. S., Tarun, E. I., Kupriyanov, A. N., Khrustaleva, I. A., ... & Shabunya, P. G. (2019). The composition of biologically active substances of extracts of yarrow flowers of the native flora of Belarus, Kazakhstan and Russia, their antioxidant properties and toxicity. Ecobiotech , 2 (3), 286-292. https://doi.org/10.31163/2618-964X-2019-2-3-286-292
21. Jatdoeva, D. T. (2022). Studying the composition of medicinal plants in the prevention of infectious diseases based on biochemical mechanisms. Bulletin of the Kursk State Agricultural Academy , (9), 88-93.
22. Candan, F., Unlu, M., Tepe, B., Daferera, D., Polissiou, M., Sökmen, A., & Akpulat, H. A. (2003). Antioxidant and antimicrobial activity of the essential oil and methanol extracts of Achillea millefolium subsp. millefolium Afan.(Asteraceae). Journal of ethnopharmacology, 87(2-3), 215-220. https://doi.org/10.1016/S0378-8741(03)00149-1
23. El-Kalamouni, S., Venskutonis, P. R., Zebib, B., Mera, O., Reynaud, S., & Talu, T. (2017). Antioxidant and antimicrobial activity of Achillea millefolium L. essential oil grown in France. Medicinal Products, 4(2), 30. https://doi.org/10.3390/medicines4020030.
24. Mazandarani, M., Mirdeylami, S. Z., & Pessarakli, M. (2013). Composition of essential oil and antibacterial activity of Achillea millefolium L. from different regions of northeastern Iran. Journal of Medicinal Plant Research, 7(16), 1063-1069. https://doi.org/10.5897/JMPR12.961.
25. Santoro, G. F., Cardoso, M. G., Guimar alzes, L. G. L., Mendon minnesa, L. Z., & Soares, M. J. (2007). Trypanosoma cruzi: Activity of essential oils from Achillea millefolium L., Syzygium aromaticum L. and Ocimum basilicum L. on epimastigotes and trypomastigotes. Experimental Parasitology, 116(3), 283-290. https://doi.org/10.1016/j.exppara.2007.01018.
26. Howyzeh, M. S., Aslani, S., & Pooraskari, O. (2019). Essential oil profile of an Iranian yarrow (Achillea millefolium). Journal of Essential Oil Bearing Plants, 22(1), 295-300. https://doi.org/10.1080/0972060X.2019.1586589
27. Stoletov, Yu. V., & Ulanova, V. A. (2020). The use of common yarrow (Achillea millefólium L.) in folk and official medicine, the prospects for its use. https://doi.org/10.36074/18.09.2020.v2.26
28. Akhmetyanov, R. T., Khasanova, Z. M., & Khasanova, L. A. (2019). Yarrow (Achillea millefolium L.) as a basis for functional products. Bulletin of the Bashkir State Pedagogical University. M. Akmulla , (1 (49)), 6-11.
29. Chusovitina, K. A., & Karpukhin, M. Yu. (2019). Pharmacological features of common yarrow (Achillea millefolium L.). Agricultural Education and Science , (4), 31.
Published
2023-07-09
How to Cite
Istamkulova M.M, Mukhamadiev N.K, Keldiyarov O.X, Makhmudova G.N, & Mukhamadiev A.N. (2023). Gc-Ms Analysis of the Chemical Composition of Essential Oil Isolated From Achillea Millefolium L. Central Asian Journal of Medical and Natural Science, 4(4), 46-54. https://doi.org/10.17605/cajmns.v4i4.1659
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