Stem Cell Therapy for Alzheimer’s Disease Treatment

  • Supriya Chaudhary Agra, Uttar Pradesh, India
Keywords: stem cell therapy, Alzheimer’s disease, dementia, amyloid protein, anti-anxiety drugs, clinical trials

Abstract

Stem cell therapy is a unique approach to treating Alzheimer’s Disease. It involves the systemic introduction of Mesenchymal Stem Cells into the body via IV. When introduced in large quantities, these stem cells can find inflammation within the body and repair it. This unique property of stem cells is what potentially makes them a viable treatment for Alzheimer’s Disease. Alzheimer's disease, a form of dementia that affects memory, thinking, and behavior, is a growing public health concern. According to the Alzheimer's Association, an estimated 6.2 million Americans are living with Alzheimer's, and this is projected to rise to nearly 14 million by 2050. One of the hallmarks of Alzheimer's disease is the presence of amyloid protein deposits in the brain. While current Alzheimer's treatments, including anti-anxiety drugs, aim to treat the symptoms of moderate Alzheimer's, there is a need for more effective treatments that can slow or halt the progression of the disease. In recent years, stem cell therapy has emerged as a promising potential treatment for Alzheimer's, and several clinical trials are underway to determine the safety and efficacy of this approach.

References

1. Knopman DS, Amieva H, Petersen RC, et al. (May 2021). "Alzheimer disease". Nat Rev Dis Primers. 7 (1): 33. doi:10.1038/s41572-021-00269-y. PMC 8574196. PMID 33986301.
2. "Dementia Fact sheet". World Health Organization. September 2020.
3. Ganguli M, Dodge HH, Shen C, Pandav RS, DeKosky ST (May 2005). "Alzheimer disease and mortality: a 15-year epidemiological study". Archives of Neurology. 62 (5): 779–784. doi:10.1001/archneur.62.5.779. PMID 15883266.
4. Mendez MF (November 2012). "Early-onset Alzheimer's disease: nonamnestic subtypes and type 2 AD". Archives of Medical Research. 43 (8): 677–685. doi:10.1016/j.arcmed.2012.11.009. PMC 3532551. PMID 23178565.
5. "Dementia diagnosis and assessment" (PDF). National Institute for Health and Care Excellence (NICE). Archived from the original (PDF) on 5 December 2014. Retrieved 30 November 2014.
6. Gomperts SN (April 2016). "Lewy Body Dementias: Dementia With Lewy Bodies and Parkinson Disease Dementia". Continuum (Review). 22 (2 Dementia): 435–463. doi:10.1212/CON.0000000000000309. PMC 5390937. PMID 27042903.
7. Lott IT, Head E (March 2019). "Dementia in Down syndrome: unique insights for Alzheimer disease research". Nat Rev Neurol. 15 (3): 135–147. doi:10.1038/s41582-018-0132-6. PMC 8061428. PMID 30733618.
8. Commission de la transparence (June 2012). "Drugs for Alzheimer's disease: best avoided. No therapeutic advantage" [Drugs for Alzheimer's disease: best avoided. No therapeutic advantage]. Prescrire International. 21 (128): 150. PMID 22822592.
9. Querfurth HW, LaFerla FM (January 2010). "Alzheimer's disease". The New England Journal of Medicine. 362 (4): 329–344. doi:10.1056/NEJMra0909142. PMID 20107219. S2CID 205115756.
10. Breijyeh Z, Karaman R (December 2020). "Comprehensive Review on Alzheimer's Disease: Causes and Treatment". Molecules (Review). 25 (24): 5789. doi:10.3390/molecules25245789. PMC 7764106. PMID 33302541.
11. Simon RP, Greenberg DA, Aminoff MJ (2018). Clinical neurology (Tenth ed.). [New York]: McGraw Hill. p. 111. ISBN 978-1-259-86173-4. OCLC 1012400314.
12. Burns A, Iliffe S (February 2009). "Alzheimer's disease". BMJ. 338: b158. doi:10.1136/bmj.b158. PMID 19196745. S2CID 8570146.
13. "Alzheimer's Disease Fact Sheet". National Institute on Aging. Retrieved 25 January 2021.
14. Todd S, Barr S, Roberts M, Passmore AP (November 2013). "Survival in dementia and predictors of mortality: a review". International Journal of Geriatric Psychiatry. 28 (11): 1109–1124. doi:10.1002/gps.3946. PMID 23526458. S2CID 25445595.
15. Long JM, Holtzman DM (October 2019). "Alzheimer Disease: An Update on Pathobiology and Treatment Strategies". Cell. 179 (2): 312–339. doi:10.1016/j.cell.2019.09.001. PMC 6778042. PMID 31564456.
16. "Study reveals how APOE4 gene may increase risk for dementia". National Institute on Aging. 16 March 2021. Retrieved 17 March 2021.
17. Hsu D, Marshall GA (2017). "Primary and secondary prevention trials in Alzheimer disease: looking back, moving forward". Curr Alzheimer Res. 14 (4): 426–440. doi:10.2174/1567205013666160930112125. PMC 5329133. PMID 27697063.
18. Thompson CA, Spilsbury K, Hall J, Birks Y, Barnes C, Adamson J (July 2007). "Systematic review of information and support interventions for caregivers of people with dementia". BMC Geriatrics. 7: 18. doi:10.1186/1471-2318-7-18. PMC 1951962. PMID 17662119.
19. Forbes D, Forbes SC, Blake CM, Thiessen EJ, Forbes S (April 2015). "Exercise programs for people with dementia". The Cochrane Database of Systematic Reviews (Submitted manuscript). 132 (4): CD006489. doi:10.1002/14651858.CD006489.pub4. PMC 9426996. PMID 25874613.
20. National Institute for Health and Clinical Excellence. "Low-dose antipsychotics in people with dementia". National Institute for Health and Care Excellence (NICE). Archived from the original on 5 December 2014. Retrieved 29 November 2014.
21. "Information for Healthcare Professionals: Conventional Antipsychotics". US Food and Drug Administration. 16 June 2008. Archived from the original on 29 November 2014. Retrieved 29 November 2014.
Published
2023-06-19
How to Cite
Chaudhary, S. (2023). Stem Cell Therapy for Alzheimer’s Disease Treatment. Central Asian Journal of Medical and Natural Science, 4(3), 1079-1086. https://doi.org/10.17605/cajmns.v4i3.1627
Section
Articles