The relationship between leptin, thyroid hormone and insulin resistance in obese diabetic patients

Osama A.  mohsein; Mahdi M.  Thuwaini; Hanaa k.  salman

doi:10.17605/cajmns.v4i3.1560

Osama A. mohsein College of Medical and Healthy Techniques, Southern Technical University- Basrah, Iraq
Mahdi M. Thuwaini College of Medical and Healthy Techniques, Southern Technical University- Basrah, Iraq
Hanaa k. salman College of Science, University of Basra

DOI: https://doi.org/10.17605/cajmns.v4i3.1560

Keywords: obesity, adipocytokines, biomarkers, type 2 diabetes Mellitus, hypothyroidism

Abstract

Background; Globally, obesity is a health crisis. Obesity raises the risk of CVD, T2DM, musculoskeletal problems, digestive system diseases, respiratory issues, and psychological issues that might interfere with daily life. It might kill you. Overweight and obesity are health risks, according to the World Health Organization. A BMI of 30 kg/m2 or higher defines obesity. Type 2 diabetes and obesity are intricately related. Type 2 diabetes patients are 90% overweight. Insulin resistance, a key pathogenesis of type 2 diabetes, is mediated by obesity-induced chronic inflammation. In obese diabetic patients, we examined the diagnostic and follow-up value of specific adipokines(Leptin) and thyroid indicators (FT3,FT4,TSH).

Methodology: The study comprised 50 overweight and 50 obese women, as well as a control group of 70 healthy, normal-weight women who came to Thi-qar to attend the Al-habobi and AL-naseriah Teaching Hospital between October 1, 2022, and February 2, 2023. Leptin was measured using an enzyme-linked immunosorbent assay (ELISA). Thyroid hormone (FT3, FT4, and TSH) was also measured using an electrochemiluminescence (ECLIA) immunoassay. FBS was measured using a colorimetric technique, while HBA1C was measured using a fluorescence immunoassay (FIA).

Results; Leptin levels were significantly lower in obese diabetic patients compared to age-matched healthy controls, and FT4 levels were significantly lower in obese diabetic patients compared to age-matched healthy controls, according to the current study. Instead, FT3 and TSH are increased.

Conclusions: From our results, we can conclude the relashinship between thyroid hormone and leptin have a value in the diagnosis and follow-up of a patient’s obese diabetic.

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