Structural Changes in the Prostate of 3-Month-Old Rats with Chronic Alcoholism

Radjabov A.  B.

doi:10.17605/cajmns.v4i3.1526

Radjabov A. B. Bukhara State Medical Institute

DOI: https://doi.org/10.17605/cajmns.v4i3.1526

Keywords: rat prostate, gland, morphometry, chronic alcoholism

Abstract

The article presents the results of a study on the histological relationship of glandular and non-glandular structures of the prostate gland of 3-month-old rats and its structural changes in chronic alcoholism.

In rats with chronic alcoholism, compared with the control, there is polymorphism of the terminal sections of the glands, an increase in the volume fraction of acini that do not contain a secret, and a decrease in the volume fraction of the glandular parenchyma in the structure of the organ. The experiment revealed acini with foci of epithelial stratification, vascular changes, mild and moderate lymphocytic infiltration, expansion of connective tissue layers, proliferation of fibrous connective tissue and compaction of bundles of collagen fibers.

References

1. Koptyaeva K.E., Muzhikyan A.A., Gushchin Ya.A., Belyaeva E.V., Makarova M.N., Makarov V.G. Method of autopsy and extraction of organs of laboratory animals // Message 1: rat. Laboratory animals for scientific research. - 2018. - No. 2. - C. 71-92. DOI: 10.29296/10.29296/2618723X-2018-02-08.
2. Sidorov P.I. The use of laboratory animals in a toxicological experiment: guidelines. Ed. Sidorova P.I. - Arkhangelsk. - 2002; 15 s.
3. Trotsenko B.V. Regional heterogeneity of the mesenchyme in the processes of prostate morphogenesis in human fetuses and rats / B.V. Trotsenko, I.A. Lugin // Morphology. 2009 V.3 No. 3. pp.126-130.
4. Linda M. Ernest Color Atlas of fetal and neonatal histology / M. Ernest Linda, Eduardo D. Ruchelli, Dale S. Huff // Springer. 2011. 399p.
5. Rocco A., Compare D., Angrisani D., Sanduzzi Zamparelli M., Nardone G. Alcoholic disease: liver and beyond / World J. Gastroenterol. 2014; 20(40): 14652-9.