Modern Views and Approaches to Pathophysiological Bases of Endogenous Intoxication
Keywords:
endogenous intoxication, lipid peroxidation
Abstract
Recently, many scientific works have been devoted to the study of endogenous intoxication (EI) in various pathological diseases and conditions, since EI is one of the most important criteria that determine the severity of a person's condition. EI (endotoxicosis) is a pathophysiological process characterized by the formation and accumulation of various compounds and metabolites in tissues and body fluids in excessive concentrations or forms that are not characteristic of normal metabolism. In the development of EI among biochemical processes, much attention is paid to the activation of proteolysis with a violation of the general enzymatic homeostasis of the body. The metabolic level of endotoxicosis is characterized by excessive accumulation of products of normal and pathologically perverted metabolism and is detected using biochemical and other laboratory methods. The clinical level of endotoxicosis includes both metabolic disorders and various clinical manifestations in the form of complications in the course of the underlying disease and side effects of therapy.
References
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Nazirov F.G., Akilov Kh.A., Devyatov A.V. Surgery of portal hypertension complications in patients with liver cirrhosis. - Moscow: GEOTAR Medicine.
Nazirov F.G., Akilov H.A., Ibadov R.A., Asabaev A.Sh., Zainutdinov U.I., Khafizov B.B. Some pathogenetic aspects of liver failure and its prevention in patients with cirrhosis after portosystemic shunting. // Bulletin of Surgery named after I.I. Grekov. I.I. Grekov. 2002. -№1, -С. 87-90.
Nazirov F.G., Ibadov R.A. Standardization of treatment tactics of hepatic encephalopathy in patients with cirrhosis after surgical intervention // Сәrgahіuә. Baku, 2011. - №3 (27) - P. 41-43.
Saenko V.F., Pertseva G.A., Shapovalyuk V.V. // Sepsis and multiple organ failure. - К., 2003. - 273 с.
Sinkov S.V. Prediction of various forms of postoperative acute liver failure. Anaesthesiology and intensive care. 2017;62(1). С. 73-76Butterworth R.F. Pathophysiology of hepatic encephalopathy: The concept of synergism // Hepatol. Reseach. – 2008. – Vol.38. – №1. – P. 116 – 121.
Chen HL, Wu SH, Hsu SH, Liou BY, Chen HL, Chang MH. Jaundice revisited: recent advances in the diagnosis and treatment of inherited cholestatic liver diseases. J. Biomed. Sci. 2018 Oct 26;25(1):75.
Colomina-Climent F, Giménez-Esparza C, Portillo-Requena C, Allegue-Gallego JM, et al. Mortality reduction in septic shock by plasma adsorption (ROMPA): a protocol for a randomised clinical trial. BMJ Open 2016; 6:e011856.
Dullah EC, Ongkudon CM. Current trends in endotoxin detection and analysis of endotoxin-protein interactions. //Crit Rev Biotechnol. 2017 Mar;37(2):251-261. doi: 10.3109/07388551.2016.1141393. Epub 2016 Feb 10.
Edmark C, McPhail MJ, Bell M, Whitehouse T, Wendon J, Christopher KB. LiFe: a liverinjury score to predict outcome in critically ill patients. //Intensive Care Med. 2016 Mar; 42 (3):361-9.
Felipo V., Urios A., Montesinos E. et al.Contributionofhyperammonemiaand inflammatory factors to cognitive impairment in minimal hepatic encephalopathy //Metabol Brain Dis. – 2012. – Vol.27. – P. 51 – 58.
Fukui H. Increased Intestinal Permeability and Decreased Barrier Function: Does It Really Influence the Risk of Inflammation?. InflammIntest Dis. 2016;1(3):135-145. doi:10.1159/000447252
González-Navajas J.M. Inflammasome activation in decompensated liver cirrhosis. //World J Hepatol. 2016. Feb. 8; 8(4): Р.207-10.
G. M. HODJIMATOV, K. K. MIRZAEV, D. T. AZIZOV. PHARMACOKINETICS OF ANTIBIOTICS IN EXPERIMENTAL GUNSHOT WOUNDS. A Multidisciplinary Peer Reviewed Journal Research for Revolution ISSN No-2581 – 4230,Is Published Online in Volume-7, Issue2, Feb. – 2021,pp120-123
G. M. HODJIMATOV, Kh. Kh. Hamdamov. DIAGNOSTICS AND TREATMENT OF CHOLEDOCHOLITIASIS IN ELDERLY AND SENILE AGE PATIENTS // European Journal of Research Development and Sustainability (EJRDS) Available Online at: https://www.scholarzest.com Vol. 2 No. 3, March 2021, ISSN: 2660-5570
Kamalova M. I., Islamov Sh. E., Khaydarov N.K.// MORPHOLOGICAL CHANGES IN BRAIN VESSELS IN ISCHEMIC STROKE. Journal of Biomedicine and Practice 2020, vol. 6, issue 5, pp.280-284
Khamdamov B.Z. Indicators of immunocitocine status in purulent-necrotic lesions of the lover extremities in patients with diabetes mellitus.//American Journal of Medicine and Medical Sciences, 2020 10 (7) 473-478 DOI: 10.5923/j.ajmm.2020.- 1007.08
Ibadov R. A., Gizatulina N.R., BabadjanovA.Kh. Clinical Signs of the Development of Acute Hepatocellular Insufficiency and Ways to Prevent it, in Patients with Liver Cirrhosis After Porto-Systemic Shunting // © Springer Science+Business Media B.V. 2011. – P.235-239.
Ince C. The microcirculation in the motor of sepsis // Crit. care. — 2005. — Vol. 9, №4. — P. 19.
Kandiah PA, Olson JC, Subramanian RM. Emergingstrategiesforthe treatment of patients with acute hepatic failure. //CurrOpinCrit Care. 2016. Feb 4.
O. U. Rakhmatullaeva, Kh. E. Shomurodov, A. A. Hadjimetov, X. Kh. Sadiqova, Z. Z. Nazarov. (2021). The Position of the Cytokine Profile and Cytolysis Enzymes in Patients with Viral Hepatitis before Tooth Extraction. Annals of the Romanian Society for Cell Biology, 6558 -. Retrieved from http://annalsofrscb.ro/index.php/journal/article/view/8233.
Ma H, Shi X, Yuan X, Ding Y. IL-1β siRNAadenovirusbenefits liver regeneration by improving mesenchymal stem cells survival after acute liver failure.//AnnHepatol. 2016. Mar-Apr.
Méndez M., Méndez-López M., López L. et al.Portosystemichepaticencephalopathymodel show reversal learning impairment and dysfunction of neural activity in the prefrontal cortex and regions involved in motivated behavior //J. Clin. Neuroscience. – 2011. – Vol.18. – №1. – P. 690 – 694.
Sarin SK, Choudhury A. Acute-on-chronic liver failure: terminology, mechanisms and management. // Nat Rev GastroenterolHepatol. 2016. Feb 3. doi: 10. 1038. / nrgastro. 2015. 219.
Shi X.L., Gao Y., Yan Y. et all. Improvedsurvivalofporcine acute liver failure by a bioartificial liver device implanted with induced human functional hepatocytes. //Cell Res. 2016. Jan 15. Р. 1013-18
Vogt A, Reuken PA, Stengel S, Stallmach A, Bruns T. Dual-sugartestsofsmall intestinal permeability are poor predictors of bacterial infections and mortality in cirrhosis: A prospective study. //World J Gastroenterol. 2016. Mar 21; 22 (11): Р.3275-84.
Wang X, Wang B, Huang Q, Zhang B, Hua Z. Regulation of hydrogen sulfide on transporter protein Bsep and Mdr2 in acute liver failure. //Zhonghua Yi XueZaZhi. 2015. Oct.
Wang Z.L., Gao S., Li L., Li X.Y., Huan S.L., Wang K. Demethylationoftumornecrosis factor-α converting enzyme predicts poor prognosis in acute-on-chronic hepatitis B liver failure. //Clin Res HepatolGastroenterol. 2016. Feb 2. pii: S. 2210-11
Yan BZ, Yang BS, Li H, Zhang YF. et all. Thetherapeuticeffectof CORM-3 on acute liver failure induced by lipopolysaccharide/D-galactosamine in mice. //Hepatobiliary Pancreat Dis Int. 2016. Feb. P 73-80.
Published
2021-03-30
How to Cite
Sadikov Rustam Abrarovich, Khakimov Dilshodbek Mamadalievich, & Кasimov Nosirbek Adxamovich. (2021). Modern Views and Approaches to Pathophysiological Bases of Endogenous Intoxication. Central Asian Journal of Medical and Natural Science, 2(2), 140-148. https://doi.org/10.17605/cajmns.v2i2.144
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