Modern Views and Approaches to Pathophysiological Bases of Endogenous Intoxication

  • Sadikov Rustam Abrarovich Doctor of Medical Sciences, Professor, Head of the Department of Experimental Surgery of the Republican specialized center of surgery named of academician V. Vakhidov
  • Khakimov Dilshodbek Mamadalievich Doctor of Medical Sciences, Head of the Department of General Surgery, Fibroendoscopy and Anesthesiology-Reanimatology of the Faculty of Advanced Training and Retraining of Doctors of the Andijan State Medical Institute
  • Кasimov Nosirbek Adxamovich Assistant of the Department of General Surgery, Fibroendoscopy and Anesthesiology-Reanimatology of the Faculty of Advanced Training and Retraining of Doctors of the Andijan State Medical Institute
Keywords: endogenous intoxication, lipid peroxidation


Recently, many scientific works have been devoted to the study of endogenous intoxication (EI) in various pathological diseases and conditions, since EI is one of the most important criteria that determine the severity of a person's condition. EI (endotoxicosis) is a pathophysiological process characterized by the formation and accumulation of various compounds and metabolites in tissues and body fluids in excessive concentrations or forms that are not characteristic of normal metabolism. In the development of EI among biochemical processes, much attention is paid to the activation of proteolysis with a violation of the general enzymatic homeostasis of the body. The metabolic level of endotoxicosis is characterized by excessive accumulation of products of normal and pathologically perverted metabolism and is detected using biochemical and other laboratory methods. The clinical level of endotoxicosis includes both metabolic disorders and various clinical manifestations in the form of complications in the course of the underlying disease and side effects of therapy.


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How to Cite
Sadikov Rustam Abrarovich, Khakimov Dilshodbek Mamadalievich, & Кasimov Nosirbek Adxamovich. (2021). Modern Views and Approaches to Pathophysiological Bases of Endogenous Intoxication. Central Asian Journal of Medical and Natural Science, 2(2), 140-148.