The Role of Oxidative Stress and its Antioxidants in Patients with Plaque Psoriasis in the City of Samarra
Keywords:
Psoriasis, Oxidative stress and its antigens, Tumor necrosis factor alpha (TNF-a), Interleukin IL-18
Abstract
The study was for the period from September 1 to December 1, 2022, when (60) samples were collected, divided into two groups, a control group of 30 people and 30 people for a group of plaque psoriasis. Medical outpatient clinics. All of the oxidative stress represented by MDA and the antioxidants catalase enzyme CAT were measured, as well as the study of immunological variables represented by the rate of alpha tumor necrosis factor (TNF-a) and the rate of interleukin IL-18. The results showed a significant increase in malondaldehyde (MDA), catalase enzyme (CAT), tumor necrosis factor-alpha (TNF-a) and interleukin (IL-18). Compared to the control group at a significant level of P ≤ 0.05.
References
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10. Jasim Suzan Yousif.(2017). The Roloe of IL-18, Tnf-a and hs-CRP among Iraqi Psoriatic patients and their Correlation with Disease Sererity. Mustansiriyah University. 12,No.1.
11. Mahmaod Dhurghan Adil.(2022). Study of Paraoxonase-1 and some Biochemical Parameters in Patiens .With Psoriasis. Master thesis. Collage of Medicine . Tikrit University.
12. Nakanishi K, Yoshimoto T, Tsutsui,H.( 2001). Interleukine 18 regulates both Th1and Th2 responses. Annu.Rev.Immunol. 19. Pp:423-474.
13. Raquel Rivera, E. Vilarrasa, M. Ribera, E. Roe, T. Kueder-Pajares, A. I. Zayas, L. Martínez-Molina, J. Mataix Díaz, I. M. Rodríguez-Nevado, T. UseroBárcena, D. de la Mano, C. García-Donoso, A. Olveira, G. Guinea, V. MartínVázquez & M. Ferran. (2020).Unmet needs in patients with moderate-to-severe plaque psoriasis treated with methotrexate in real world practice: FirST study, Journal of Dermatological Treatment.
14. Rocha-PereiraP.,Santos-SilvaA.,RebeloI.ettil. (2001). Dislipidemia and oxidative stress in mild and in severe psoriasis as a rink lor car¬diovascular disease.ClinChlmActa : 303: 33-9.
15. Shakoei S, Nakhjavani M, Mirmiranpoor H, Motlagh MA, Azizpour A, Abedini R. (2021) The Serum Level of Oxidative Stress and Antioxidant Markers in Patients with Psoriasis: A Cross-sectional Study. J Clin Aesthet Dermatol. Jul;14(7):38-41. Epub Jul 1. PMID: 34840649; PMCID: PMC8570352.
16. Williams JD, Griffiths CE.(2002).Cytokine blocking agents in dermatology. Clin. Exp. Dermatol. 27 (7) . Pp:585-590.
17. Yoshimoto T, Takeda K, Tanaka T.(1998). IL-12 upregulates IL-18 receptor expression on T cells, Th1 cells, and B cells: synergism with IL-18 for IFN-γ production. J. Immunol.161 (7) . Pp:3400-3407.
2. AL-Jubouri Bariaa Ali Makii.(2010).Oxidants and Antioxidants status in psoriasis. Master thesis. College of Medicine. Babylon University.
3. AL-Jubouri Ibrahim Mohammed Abid.(2014). Biochemical and Genetlcal studyon Posriasis Patients and its relation With. Athero Sclerosis. PhD thesis. College of Medicine. Tikrit University.
4. AL-Zeeady fadhil .A, AL-Dhalimi Muhsin.A, AL-Sahlaulee Mahdi, m.(2013) Evalution of Inflammatory Response in Plaoue psoriasis. Journal of Kerbala University. 10,No.4 .
5. Amina Aounallah et al.( 2019). Addictive behaviors, cardiovascular and metabolic comorbidities in North African psoriatic patients: case-control study. Pan African Medical Journal.;34:205.
6. Arican O, Aral M, Sasmaz S, Ciragil P.( 2005). Serum levels of TNF-α, IFN-γ, IL-6, IL-8, IL-12, IL-17 and IL-18 in patients with active psoriasis and correlation with disease severity. Mediators Inflamm ;5:273-279.
7. Aringer, M. (2002). T-lymphocyte activation an inside overview. Acta Med Austricia; 29: 7-13.
8. Duncan, D.B. (1955).Multiple range and multiple F tests. Biometrics, 11(1), 1-42.
9. Gerdes S., A. Pinter, M. Biermann, C. Papavassilis & M. Reinhardt . (2020). Adiponectin levels in a large pooled plaque psoriasis study population, Journal of Dermatological Treatment,; 31:5, 531.
10. Jasim Suzan Yousif.(2017). The Roloe of IL-18, Tnf-a and hs-CRP among Iraqi Psoriatic patients and their Correlation with Disease Sererity. Mustansiriyah University. 12,No.1.
11. Mahmaod Dhurghan Adil.(2022). Study of Paraoxonase-1 and some Biochemical Parameters in Patiens .With Psoriasis. Master thesis. Collage of Medicine . Tikrit University.
12. Nakanishi K, Yoshimoto T, Tsutsui,H.( 2001). Interleukine 18 regulates both Th1and Th2 responses. Annu.Rev.Immunol. 19. Pp:423-474.
13. Raquel Rivera, E. Vilarrasa, M. Ribera, E. Roe, T. Kueder-Pajares, A. I. Zayas, L. Martínez-Molina, J. Mataix Díaz, I. M. Rodríguez-Nevado, T. UseroBárcena, D. de la Mano, C. García-Donoso, A. Olveira, G. Guinea, V. MartínVázquez & M. Ferran. (2020).Unmet needs in patients with moderate-to-severe plaque psoriasis treated with methotrexate in real world practice: FirST study, Journal of Dermatological Treatment.
14. Rocha-PereiraP.,Santos-SilvaA.,RebeloI.ettil. (2001). Dislipidemia and oxidative stress in mild and in severe psoriasis as a rink lor car¬diovascular disease.ClinChlmActa : 303: 33-9.
15. Shakoei S, Nakhjavani M, Mirmiranpoor H, Motlagh MA, Azizpour A, Abedini R. (2021) The Serum Level of Oxidative Stress and Antioxidant Markers in Patients with Psoriasis: A Cross-sectional Study. J Clin Aesthet Dermatol. Jul;14(7):38-41. Epub Jul 1. PMID: 34840649; PMCID: PMC8570352.
16. Williams JD, Griffiths CE.(2002).Cytokine blocking agents in dermatology. Clin. Exp. Dermatol. 27 (7) . Pp:585-590.
17. Yoshimoto T, Takeda K, Tanaka T.(1998). IL-12 upregulates IL-18 receptor expression on T cells, Th1 cells, and B cells: synergism with IL-18 for IFN-γ production. J. Immunol.161 (7) . Pp:3400-3407.
Published
2023-04-11
How to Cite
Lafta, M. F., & Abdulrahman, D. M. A. (2023). The Role of Oxidative Stress and its Antioxidants in Patients with Plaque Psoriasis in the City of Samarra. Central Asian Journal of Medical and Natural Science, 4(2), 368-372. Retrieved from https://cajmns.centralasianstudies.org/index.php/CAJMNS/article/view/1430
Section
Articles
