Enzyme Activity and Intensity of Lipid Peroxidation in AIO
Abstract
In 118 white rats, obturation from the middle part of the small intestine, strangulation by connecting with the intestinal mesentery was called in the intestinal obstruction experiment.
Dynamics of mine biochemistry and SOD (superoxide dismutase) parameters were studied. Examinations showed that all indicators showed high changes in strangulation intestinal obstruction, and when the cause of intestinal obstruction was removed, the changes did not return to their original state, polyorgan failure
Against the background of impaired microcirculation, hemorheology, and developing endotoxemia and hypoxia, the antioxidant defense system is weakened, which may be the cause of a violation of the structural integrity of biomembranes. One of the factors leading to membrane destabilization under hypoxic conditions is the activation of phospholipase A2, which leads to the breakdown of membrane phospholipids and the release of polyunsaturated fatty acids, which are the main substrates of LPO.
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