The Diabetic II Neuropathy and the Gene Polymorphism in the P636 Temperature Regulations
Keywords:
eNOS polymorphism, ACE polymorphism, Type 2 diabetes, Metabolic syndrome, Ray syndrome
Abstract
A significant role for multigenetic predisposition in the development of diabetic nephropathy (DN) coheres with considerable variation in the incidence and prevalence of DN. Some of the genes that are likely involved in the development of diabetic nephropathy also control blood pressure, familial hyperlipidemia, familial hypertension, and other cardiovascular illnesses. The insertion/deletion polymorphism in the angiotensin-converting enzyme gene, the G/T polymorphism in the glucose transporter 1 gene, the G/T (894) polymorphism, and the T/C (-786) polymorphism in the eNOS gene were all examined in three groups of patients with diabetes mellitus to see if they were associated with diabetic nephropathy, non-diabetic nephropathy.
References
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2. Miyata T., Novel mechanisms and therapeutic options in diabetic nephropathy, Pol. Arch. Med. Wewn, 2009, 119, 261-264
3. Maeda Y., Shiigai T., Diet therapy in diabetic nephropathy, Contrib. Nephrol., 2007, 155, 50-58
4. Pettitt D.J., Forman M.R., Hanson R.L., Knowler W.C., Bennett P.H., Breastfeeding and incidence of non-insulin-dependent diabetes mellitus in Pima Indians, Lancet, 1997, 350, 166-168
5. Freedman B.I., Bowden D.W., The role of genetic factors in the development of end-stage renal disease, Curr. Opin. Nephrol. Hypertens., 1995, 4, 230-234
6. Quinn M., Angelico M.C., Warram J.H., Krolewski A.S., Familial factors determine the development of diabetic nephropathy in patients with IDDM, Diabetologia, 1996, 39, 940-945Schmidt S., Rit.,Angiotensin I converting enzyme gene polymorphism and diabetic nephropathy in type II diabetes, Nephrol. Dial. Transplant., 1997, 12, Suppl.2, 37-41
7. Rigat C., Alhenc-Gelas F., Cambien F., Corvol P., Soubrier F., An insertion/deletion polymorphism in the angiotensin I-converting enzyme gene accounting for half the variance of serum enzyme levels, J. Clin. Invest., 1990, 86, 1343-1346
8. Harden P.N., Geddes C., Rowe P.A., McIlroy J.H., Boulton-Jones M., Rodger R.S., et al., Polymorphisms in angiotensin-converting-enzyme gene and progression of IgA nephropathy, Lancet, 1995, 345, 1540-1542
9. Niu T., Xu X., Rogus J., Zhou Y., Chen C., Yang J., et al., Angiotensinogen gene and hypertension in Chinese, J. Clin. Invest., 1998, 101, 188-194
10. Hodgkinson A.D., Page T., Millward B.A., Demaine A.G., A novel polymorphism in the 5’ flanking region of the glucose transporter (GLUT1) gene is strongly associated with diabetic nephropathy in patients with type 1 diabetes mellitus, J. Diabetes Complications, 2005, 19, 65-69
11. Brosius F.C., Heilig C.W., Glucose transporters in diabetic nephropathy, Pediatr. Nephrol., 2005, 20, 447-451
12. Nannipieri M., Penno G., Pucci L., Colhoun H., Motti C., Bertacca A., et al., Pronatriodilatin gene polymorphisms, microvascular permeability, and diabetic nephropathy in type 1 diabetes mellitus, J. Am. Soc. Nephrol., 1999, 10, 1530-1541
13. Watarai A., Nakashima E., Hamada Y., Watanabe G., Naruse K., Miwa K., et al., Aldose reductase gene is associated with diabetic macroangiopathy in Japanese type 2 diabetic patients, Diabet. Med., 2006, 23, 894-899
14. Romzova M., Hohenadel D., Kolostova K., Pinterova D., Fojtikova M., Ruzickova S., et al., NFkappaB and its inhibitor IkappaB in relation to type 2 diabetes and its microvascular and atherosclerotic complications, Hum. Immunol., 2006, 67, 706-713
15. Zanchi A., Moczulski D.K., Hanna L.S., Wantman M., Warram J.H., Krolewski A.S., Risk of advanced diabetic nephropathy in type 1 diabetes is associated with endothelial nitric oxide synthase gene polymorphism, Kidney. Int., 2000, 57, 405-413
16. Liao L., Lim M.C., Chan S.W., Zhao J.J., Lee KO., Nitric oxide synthase gene polymorphisms and nephropathy in Asians with type 2 diabetes, J. Diabetes Complications, 2006, 20, 71-75
17. Borg H., Arnqvist H.J., Björk E., Bolinder J., Eriksson J.W., Nyström L., et al, Evaluation of the new ADA and WHO criteria for classification of diabetes mellitus in young adult people (15-34 yrs) in the Diabetes Incidence Study in Sweden (DISS), Diabetologia, 2003, 46,173-181, Erratum in, Diabetologia, 2004, 47, 154
18. Guldiken B., Sipahi T., Guldiken S., Ustundag S., Budak M., Turgut N., et al., Glu298Asp polymorphism of the endothelial nitric oxide synthase gene in Turkish patients with ischemic stroke, Mol. Biol. Rep, 2009, 36, 1539-1543
19. Thameem F., Puppala S., Arar N.H., Stern M.P., Blangero J., Duggirala R., et al., Endothelial nitric oxide synthase (eNOS) gene polymorphisms and their association with type 2 diabetes-related traits in Mexican Americans, Diab. Vasc. Dis. Res., 2008, 5, 109-113
20. Fatini C., Sofi F., Sticchi E., Bolli P., Sestini I., Falciani M., et al., eNOS G894T polymorphism as a mild predisposing factor for abdominal aortic aneurysma, J. Vasc. Surg., 2005, 42, 415-419
21. Giusti B., Gori A.M., Marcucci R., Sestini I., Saracini C., Sticchi E., et al., Role of C677T and A1298C MTHFR, A2756G MTR and -786 T/C eNOS gene polymorphisms in atrial fibrillation susceptibility, PLoS One, 2007, 2, e495
22. Freitas-Silva M., Pereira D., Coelho C., Bicho M., Lopes C., Medeiros R., Angiotensin I-converting enzyme gene insertion/deletion polymorphism and endometrial human cancer in normotensive and hypertensive women, Cancer. Genet. Cytogenet., 2004, 155, 42-46
23. Hodgkinson A.D., Millward B.V., Demaine A.G., Polymorphism of the glucose transporter (GLUT1) gene is associated with diabetic nephropathy, Kidney Int., 2001, 59, 985-989
24. Schmidt S., Ritz E., Genetic determinants of diabetic renal disease and their impact on therapeutic interventions, Kidney Int. Suppl., 1997, 63, S27-31
25. Tarnow L., Gluud C., Parving H.H., Diabetic nephropathy and the insertion/deletion polymorphism of the angiotensin-converting enzyme gene, Nephrol. Dial. Transplant., 1998, 13, 1125-1130
26. Hadjadj S., Tarnow L., Forsblom C., Kazeem G., Michel Marre, Groop P-H., et al., FD Study Group, Hager-Vionnet N, for the EURAGEDIC Study Group, Association between Angiotensin- Converting Enzyme Gene Polymorphisms and Diabetic Nephropathy, Case-Control, Haplotype, and Family-Based Study in Three European Populations, J. Am. Soc. Nephrol., 2007, 18, 1284–1291
27. Movva S., Alluri R.V., Komandur S., Vattam K., Eppa K., Mukkavali K.K., et al., Relationship of angiotensin-converting enzyme gene polymorphism with nephropathy associated with Type 2 diabetes mellitus in Asian Indians, J Diabetes Complications, 2007, 21, 237–241
28. Boström K.B., Hedner J., Melander O., Grote L., Gullberg B., Råstam L., et al., Interaction between the angiotensin-converting enzyme gene insertion/ deletion polymorphism and obstructive sleep apnoea as a mechanism for hypertension, J. Hypertens., 2007, 25, 779-783
29. Parving H-H., de Zeeuw D., Cooper M.E., Remuzzi G., Liu N., Lunceford J., et al., ACE Gene Polymorphism and Losartan Treatment in Type 2 Diabetic Patients With Nephropathy, J. Am. Soc. Nephrol., 2008, 19, 771–779
30. Ruggenenti P., Bettinaglio P., Pinares F., Remuzzi G., Angiotensin Converting Enzyme Insertion/ Deletion Polymorphism and Renoprotection in Diabetic and Nondiabetic Nephropathies, Clin. J. Am. Soc. Nephrol., 2008, 3, 1511–1525
31. Ezzidi I., Mtiraoui N., Kacem M., Chaieb M., Mahjoub T., Almawi W.Y., Identification of specific angiotensin-converting enzyme variants and haplotypes that confer risk and protection against type 2 diabetic nephropathy, Diabetes Metab. Res. Rev., 2009, 25, 717–724
32. Tarnow L., Grarup N., Hansen T., Parving H-H., Pedersen O., Diabetic microvascular complications are not associated with two polymorphisms in the GLUT-1 and PC-1 genes regulating glucose metabolism in Caucasian type 1 diabetic patients, Nephrol. Dial. Transplant, 2001, 16, 1653-1656
33. Noiri E., Satoh H., Taguchi J., Brodsky S.V., Nakao A., Ogawa Y., et al., Association of eNOS Glu298Asp Polymorphism With End-Stage Renal Disease, Hypertension, 2002, 40, 535-540
34. Nagase S., Suzuki H., Wang Y., Kikuchi S., Hirayama A., Ueda A., et al., Association of ecNOS gene polymorphisms with end stage renal diseases, Mol. Cell. Biochem., 2003, 244,113-118
35. Ahluwalia T.S., Ahuja M., Rai T.S., Kohli H.S., Sud K., Bhansali A., et al., Endothelial nitric oxide synthase gene haplotypes and diabetic nephropathy among Asian Indians, Mol. Cell. Biochem., 2008, 314, 9-17
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Published
2022-10-22
How to Cite
Akram , R., Tahir, F., Hasnain, T., Shaheen, A., Siddique, A. B., Ali, S., & Toor, F. (2022). The Diabetic II Neuropathy and the Gene Polymorphism in the P636 Temperature Regulations. Central Asian Journal of Medical and Natural Science, 3(5), 408-419. https://doi.org/10.17605/cajmns.v3i5.1113
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Articles
