Covid-19 Induced Oxidative Damage Leading to Mitochondrial Dysfunction and Aging

Abu Bakar  Siddique; Usman  Ashraf; Sumaira  Zulfiqar; Muhammad  Adeel; Saqib  Shehzad; Shoaib  Akhtar; Muqaddas  Shaheen; Muhammad Usman  Majeed

doi:10.17605/cajmns.v3i5.1104

Abu Bakar Siddique Department of zoology, wildlife and fisheries, University of Agriculture Faisalabad
Usman Ashraf Department of Biomedical Sciences, National University of Science and Technology (NUST)
Sumaira Zulfiqar Department of biotechnology, University of Sargodha, Sargodha
Muhammad Adeel Mphil zoology, Department of zoology, wildlife and fisheries, University of Agriculture Faisalabad
Saqib Shehzad Department of Chemistry, University of Lahore Pakistan
Shoaib Akhtar Institute of chemistry, University of Sargodha
Muqaddas Shaheen Department of zoology, University of Central Punjab Lahore
Muhammad Usman Majeed Department of Chemistry, University of Sargodha

DOI: https://doi.org/10.17605/cajmns.v3i5.1104

Keywords: Covid-19, mitochondria, mitochondrial dysfunction, aging, ROS, oxidative stress, antioxidants

Abstract

Covid-19 is a viral disease with surging respiratory diseases and rising mortality rates. It is caused by severe acute respiratory syndrome corona virus 2 (SARS-CoV-2) with several clinical symptoms and taken the world into severe crises. Viruses target specific cell organelles like mitochondria, nucleus, peroxisomes, endoplasmic reticulum and take a way to survive and proliferate in them. Mitochondria is a key organelle which impart a vital role in host defense and immunity. COVID-19 causes several mitochondrial dysfunctions including ROS production leading to impaired functions and aging. ROS production favors the environment for increased viral infections as well as for oxidative damage. The exacerbated ROS production is one of the main causes of morbidity and mortality by this respiratory syndrome in patients susceptible to this viral infection. Here we discuss how mitochondria combat viral infection to maintain cellular homeostasis. We also enlist different steps to explain how the balance between ROS and antioxidants could be maintained to overcome severe oxidative effects of coronavirus. Finally, we discuss various steps and precautions can be taken out to improve immunity and patient’s physiological responses after being affected by coronavirus.

References

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