Potential Impact of SARS-Cov-2 on the Male and Female Reproductive Systems
Keywords:
SARS-CoV-2, COVID-19, ACE2, TMPRSS2, reproductive system, steroidogenesis, spermatogenesis
Abstract
On 29 December 2019, four cases of pneumonia of unknown etiology were reported in Wuhan, the capital of Hubei Province of China. In January 2020, sequencing the next generation of a full-size genome from respiratory tract samples of pneumonia patients revealed a new coronavirus (CoV) that had not previously been associated with an infection in humans.
References
1. Alexandre J. Vivanti, Christelle Vauloup-Fellous, Sophie Prevot, Veronique Zupan, Cecile Suffee, Jeremy Do Cao, Alexandra Benachi, Daniele De Luca. Transplacental transmission of SARS-CoV-2infection. Nature Communications (2020) 11:3572. https://doi.org/10.1038/s41467-020-17436-6
2. Ci Song, Yan Wang, Weiqin Li, Bicheng Hu, Guohua Chen, Ping Xia, Wei Wang, Chaojun Li, Feiyang Diao, Zhibin Hu, Xiaoyu Yang, Bing Yao, Yun Liu. Absence of 2019 novel coronavirus in semen and testes of COVID-19 patients. Biology of Reproduction, 2020, 103(1), 4–6 doi:10.1093/biolre/ioaa050
3. Diangeng Li, Meiling Jin, Pengtao Bao, Weiguo Zhao, ShixiZhang. Clinical Characteristics and Results of Semen Tests Among Men with Coronavirus Disease 2019. JAMA Network Open. 2020; 3(5): e208292. doi:10.1001/jamanetworkopen.2020.8292
4. Elisheva D. Shanes, Leena B. Mithal, Sebastian Otero, Hooman A. Azad, Emily S. Miller, Jeffery A. Goldstein. Placental Pathology in COVID-19. Am J Clin Pathol July 2020; 154:23-32 doi: 10.1093/ajcp/aqaa089
5. Feng Pan, Xingyuan Xiao, Jingtao Guo, Yarong Song, Honggang Li, Darshan P. Patel, Adam M. Spivak, Joseph P. Alukal, Xiaoping Zhang, Chengliang Xiong, Philip S. Li, James M. Hotaling. No evidence of severe acute respiratory syndrome–coronavirus 2 in semen of males recovering from coronavirus disease 2019. Fertility and Sterility. Vol.113, No.6, June 2020. https://doi.org/10.1016/j.fertnstert.2020.04.024
6. Feria Hikmet, Loren Méar, Аsa Edvinsson, Patrick Micke, Mathias Uhlén, Cecilia Lindskog. The protein expression profile of ACE2 in human tissues. Mol Syst Biol. (2020) 16: e9610 https://doi.org/10.15252/msb.20209610
7. George M. Bwire, Belinda J. Njiro, Dorkasi L. Mwakawanga, Deodatus Sabas, Bruno F. Sunguya. Possible vertical transmission and antibodies against SARS‐CoV‐2 among infants born to mothers with COVID‐19: A living systematic review. J Med Virol. 2021; 93:1361–1369. doi :10.1002/jmv.26622
8. Hisashi Kai, Mamiko Kai. Interactions of coronaviruses with ACE2, angiotensin II, and RAS inhibitors—lessons from available evidence and insights into COVID-19. Hypertension Research (2020) 43:648–654 https://doi.org/10.1038/s41440-020-0455-8
9. Honggang Li, Xingyuan Xiaoc, Jie Zhangd, Mohammad Ishraq Zafara, Chunlin Wue, Yuting Longb, Wei Luf, Feng Panc, Tianqing Mengb, Kai Zhaoa, Liquan Zhoua, Shiliang Shenf, Liang Liud, Qian Liud, Chengliang Xiong. Impaired spermatogenesis in COVID-19 patients. EClinicalMedicine 28 (2020) 100604. https://doi.org/10.1016/j.eclinm.2020.100604
10. Huijun Chen, Juanjuan Guo, Chen Wang, Fan Luo, Xuechen Yu, Wei Zhang, Jiafu Li, Dongchi Zhao, Dan Xu, Qing Gong, Jing Liao, Huixia Yang, Wei Hou, Yuanzhen Zhang. Clinical characteristics and intrauterine vertical transmission potential of COVID-19 infection in nine pregnant women: a retrospective review of medical records. Lancet 2020; 395: 809–15 https://doi.org/10.1016/
11. Justin K. Achua, Kevin Y. Chu, Emad Ibrahim, Kajal Khodamoradi, Katiana S. Delma, Oleksii A. Iakymenko, Oleksandr N. Kryvenko, Himanshu Arora, Ranjith Ramasamy. Histopathology and Ultrastructural Findings of Fatal COVID-19 Infections on Testis. World J Men’s Health 2021 Jan 39(1): 65-74 https://doi.org/10.5534/wjmh.200170
12. Lan Dong, Jinhua Tian, Songming. Possible Vertical Transmission of SARS-CoV-2 From an Infected Mother to Her Newborn. JAMA. 2020;323(18):1846-1848. doi:10.1001/jama.2020.4621
13. Ling Ma, Wen Xie, Danyang Li, Lei Shi, Guangming Ye, Yanhong Mao, Yao Xiong, Hui Sun, Fang Zheng, Zhimin Chen, Jyuling Qin, Jing Lyu, Yuanzhen Zhang, Ming Zhang. Evaluation of sex‐related hormones and semen characteristics in reproductive‐aged male COVID‐19 patients. Journal of Medical Virology. 2020 July 4. doi: 10.1002/jmv.26259
14. Liqiang Guo, Shengtian Zhao, Weiguang Li, Yong Wang, Leping Li, Shujuan Jiang, Wanhua Ren, Qun Yuan, Fubin Zhang, Feng Kong, Jie Lei, Mingzhen Yuan. Absence of SARS-CoV-2 in semen of a COVID-19 patient cohort. Andrology. 2021; 9:42–47. doi:10.1111/andr.12848
15. Mitko Madjunkov, Michal Dviri1, Clifford Librach. A comprehensive review of the impact of COVID-19 on human reproductive biology, assisted reproduction care and pregnancy: a Canadian perspective. Journal of Ovarian Research (2020) 13:140 https://doi.org/10.1186/s13048-020-00737-1
16. Nathalie Dejucq, Bernard Jégou. Viruses in the Mammalian Male Genital Tract and Their Effects on the Reproductive System. Microbiology and Molecular Biology Review. 2001 Jun; 65(2): 208–231. https://doi.org/10.1128/MMBR.65.2.208-231.2001
17. Nesrein M. Hashem, Sameh A. Abdelnour, Ahmad R. Alhimaidi, Ayman A. Swelum. Potential impacts of COVID-19 on reproductive health: Scientific findings and social dimension. Saudi Journal of Biological Sciences 28 (2021) 1702–1712 https://doi.org/10.1016/j.sjbs.2020.12.012
18. World Health Organization. Director-General's remarks at the media briefing on 2019-nCoV on 11 February 2020. https://www.who.int/dg/speeches/detail/who-director-general-s-remarks-at-the-media-briefing-on-2019-ncov-on-11-february-2020 (Accessed on February 12, 2020).
19. Zheng He, Yinian Fang, Qin Zuo, Xiaoxing Huang, Yongfang Lei, Xiuhua Ren, Dong Liu. Vertical transmission and kidney damage in newborns whose mothers had coronavirus disease 2019 during pregnancy. International Journal of Antimicrobial Agents 57 (2021) 106260 https://doi.org/10.1016/j.ijantimicag.2020.106260
2. Ci Song, Yan Wang, Weiqin Li, Bicheng Hu, Guohua Chen, Ping Xia, Wei Wang, Chaojun Li, Feiyang Diao, Zhibin Hu, Xiaoyu Yang, Bing Yao, Yun Liu. Absence of 2019 novel coronavirus in semen and testes of COVID-19 patients. Biology of Reproduction, 2020, 103(1), 4–6 doi:10.1093/biolre/ioaa050
3. Diangeng Li, Meiling Jin, Pengtao Bao, Weiguo Zhao, ShixiZhang. Clinical Characteristics and Results of Semen Tests Among Men with Coronavirus Disease 2019. JAMA Network Open. 2020; 3(5): e208292. doi:10.1001/jamanetworkopen.2020.8292
4. Elisheva D. Shanes, Leena B. Mithal, Sebastian Otero, Hooman A. Azad, Emily S. Miller, Jeffery A. Goldstein. Placental Pathology in COVID-19. Am J Clin Pathol July 2020; 154:23-32 doi: 10.1093/ajcp/aqaa089
5. Feng Pan, Xingyuan Xiao, Jingtao Guo, Yarong Song, Honggang Li, Darshan P. Patel, Adam M. Spivak, Joseph P. Alukal, Xiaoping Zhang, Chengliang Xiong, Philip S. Li, James M. Hotaling. No evidence of severe acute respiratory syndrome–coronavirus 2 in semen of males recovering from coronavirus disease 2019. Fertility and Sterility. Vol.113, No.6, June 2020. https://doi.org/10.1016/j.fertnstert.2020.04.024
6. Feria Hikmet, Loren Méar, Аsa Edvinsson, Patrick Micke, Mathias Uhlén, Cecilia Lindskog. The protein expression profile of ACE2 in human tissues. Mol Syst Biol. (2020) 16: e9610 https://doi.org/10.15252/msb.20209610
7. George M. Bwire, Belinda J. Njiro, Dorkasi L. Mwakawanga, Deodatus Sabas, Bruno F. Sunguya. Possible vertical transmission and antibodies against SARS‐CoV‐2 among infants born to mothers with COVID‐19: A living systematic review. J Med Virol. 2021; 93:1361–1369. doi :10.1002/jmv.26622
8. Hisashi Kai, Mamiko Kai. Interactions of coronaviruses with ACE2, angiotensin II, and RAS inhibitors—lessons from available evidence and insights into COVID-19. Hypertension Research (2020) 43:648–654 https://doi.org/10.1038/s41440-020-0455-8
9. Honggang Li, Xingyuan Xiaoc, Jie Zhangd, Mohammad Ishraq Zafara, Chunlin Wue, Yuting Longb, Wei Luf, Feng Panc, Tianqing Mengb, Kai Zhaoa, Liquan Zhoua, Shiliang Shenf, Liang Liud, Qian Liud, Chengliang Xiong. Impaired spermatogenesis in COVID-19 patients. EClinicalMedicine 28 (2020) 100604. https://doi.org/10.1016/j.eclinm.2020.100604
10. Huijun Chen, Juanjuan Guo, Chen Wang, Fan Luo, Xuechen Yu, Wei Zhang, Jiafu Li, Dongchi Zhao, Dan Xu, Qing Gong, Jing Liao, Huixia Yang, Wei Hou, Yuanzhen Zhang. Clinical characteristics and intrauterine vertical transmission potential of COVID-19 infection in nine pregnant women: a retrospective review of medical records. Lancet 2020; 395: 809–15 https://doi.org/10.1016/
11. Justin K. Achua, Kevin Y. Chu, Emad Ibrahim, Kajal Khodamoradi, Katiana S. Delma, Oleksii A. Iakymenko, Oleksandr N. Kryvenko, Himanshu Arora, Ranjith Ramasamy. Histopathology and Ultrastructural Findings of Fatal COVID-19 Infections on Testis. World J Men’s Health 2021 Jan 39(1): 65-74 https://doi.org/10.5534/wjmh.200170
12. Lan Dong, Jinhua Tian, Songming. Possible Vertical Transmission of SARS-CoV-2 From an Infected Mother to Her Newborn. JAMA. 2020;323(18):1846-1848. doi:10.1001/jama.2020.4621
13. Ling Ma, Wen Xie, Danyang Li, Lei Shi, Guangming Ye, Yanhong Mao, Yao Xiong, Hui Sun, Fang Zheng, Zhimin Chen, Jyuling Qin, Jing Lyu, Yuanzhen Zhang, Ming Zhang. Evaluation of sex‐related hormones and semen characteristics in reproductive‐aged male COVID‐19 patients. Journal of Medical Virology. 2020 July 4. doi: 10.1002/jmv.26259
14. Liqiang Guo, Shengtian Zhao, Weiguang Li, Yong Wang, Leping Li, Shujuan Jiang, Wanhua Ren, Qun Yuan, Fubin Zhang, Feng Kong, Jie Lei, Mingzhen Yuan. Absence of SARS-CoV-2 in semen of a COVID-19 patient cohort. Andrology. 2021; 9:42–47. doi:10.1111/andr.12848
15. Mitko Madjunkov, Michal Dviri1, Clifford Librach. A comprehensive review of the impact of COVID-19 on human reproductive biology, assisted reproduction care and pregnancy: a Canadian perspective. Journal of Ovarian Research (2020) 13:140 https://doi.org/10.1186/s13048-020-00737-1
16. Nathalie Dejucq, Bernard Jégou. Viruses in the Mammalian Male Genital Tract and Their Effects on the Reproductive System. Microbiology and Molecular Biology Review. 2001 Jun; 65(2): 208–231. https://doi.org/10.1128/MMBR.65.2.208-231.2001
17. Nesrein M. Hashem, Sameh A. Abdelnour, Ahmad R. Alhimaidi, Ayman A. Swelum. Potential impacts of COVID-19 on reproductive health: Scientific findings and social dimension. Saudi Journal of Biological Sciences 28 (2021) 1702–1712 https://doi.org/10.1016/j.sjbs.2020.12.012
18. World Health Organization. Director-General's remarks at the media briefing on 2019-nCoV on 11 February 2020. https://www.who.int/dg/speeches/detail/who-director-general-s-remarks-at-the-media-briefing-on-2019-ncov-on-11-february-2020 (Accessed on February 12, 2020).
19. Zheng He, Yinian Fang, Qin Zuo, Xiaoxing Huang, Yongfang Lei, Xiuhua Ren, Dong Liu. Vertical transmission and kidney damage in newborns whose mothers had coronavirus disease 2019 during pregnancy. International Journal of Antimicrobial Agents 57 (2021) 106260 https://doi.org/10.1016/j.ijantimicag.2020.106260
Published
2022-09-28
How to Cite
Askaryants, V. P., & Karataeva, L. A. (2022). Potential Impact of SARS-Cov-2 on the Male and Female Reproductive Systems. Central Asian Journal of Medical and Natural Science, 3(5), 206-211. Retrieved from https://cajmns.centralasianstudies.org/index.php/CAJMNS/article/view/1071
Section
Articles
