Prognostic Significance of the Polymorphism of the Tp-53 Oncosuppressor Gene and Mdn-2 Protoontogen in the Development of Chronic Meilid Leukemia
Keywords:
polymorphism, TP-53, oncosuppressor gene, protoontoge, chronic meilid leukemia, medicine
Abstract
The deep involvement of the TP53 gene abnormalities in the development of different types of tumors is due to its performance of a wide range of functions that prevent and/or inhibit tumor growth.
In this article highlights of prognostic significance of the polymorphism of the tp-53 oncosuppressor gene and mdn-2 protoontogen in the development of chronic meilid leukemia.
References
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7. Chumakov P.M.Versatile functions of p53 protein in multicellular organisms. // Biochemistry 2007; 72(13): 1399-1421.
8. Conrad D. F., Jakobsson M., Coop G., Wen X. et al. A worldwide survey of haplotype variation and linkage disequilibrium in the human genome. Nat Genet 2006; 38: 1251-1260.
9. Diederichs S., Bartsch L., Berkmann J.C., Frose K. et al. The dark matter of the cancer genome: aberrations in regulatory elements, untranslated regions, splice sites, non-coding RNA and synonymous mutations. EMBO Mol. Med. 2016; 8(5): 442-457.
2. Kopnin B. P., Kopnin P.B., Khromova N. V., Agapova L. S. The many-faced p53: a variety of forms, functions, tumor-suppressing and oncogenic activities. Clinical Onco-Hematology 2008; 1(1): 2-9.
3. PospelovaT.I., VoropaevaE.N., VoevodaM.I., Berezina O. V. Polymorphism of the p53 gene as a potential marker of predisposition to the development of non-Hodgkin's malignant lymphomas. Hematology and Transfusiology 2010; 55(1): 11-17.
4. AmaraK., TrimecheM., ZiadiS., LaatiriA. et al. Presence of simian virus 40 DNA sequences in diffuse large B-cell lymphomas in Tunisia correlates with aberrant promoter hypermethylation of multiple tumor suppressor genes. Int J Cancer 2007; 121(12): 2693-702.
5. AzzamG.A., Frank A. K., HollsteinM., Murphy M. E. Tissue-specific apoptotic effects of the p53 codon 72 polymorphism in a mouse model. Cell Cycle 2011; 10(9): 1352-1355.
6. Cherdyntseva N. V., DenisovE. V., Litviakov N. V., Maksimov V. N., et al. Crosstalk between the FGFR2 and TP53 genes in breast cancer: data from an association study and epistatic interaction analysis. DNA and cell biology 2011; 00(00): 1-12.
7. Chumakov P.M.Versatile functions of p53 protein in multicellular organisms. // Biochemistry 2007; 72(13): 1399-1421.
8. Conrad D. F., Jakobsson M., Coop G., Wen X. et al. A worldwide survey of haplotype variation and linkage disequilibrium in the human genome. Nat Genet 2006; 38: 1251-1260.
9. Diederichs S., Bartsch L., Berkmann J.C., Frose K. et al. The dark matter of the cancer genome: aberrations in regulatory elements, untranslated regions, splice sites, non-coding RNA and synonymous mutations. EMBO Mol. Med. 2016; 8(5): 442-457.
Published
2022-09-05
How to Cite
Khasanzoda, K. S. (2022). Prognostic Significance of the Polymorphism of the Tp-53 Oncosuppressor Gene and Mdn-2 Protoontogen in the Development of Chronic Meilid Leukemia. Central Asian Journal of Medical and Natural Science, 3(5), 5-9. https://doi.org/10.17605/cajmns.v3i5.1040
Section
Articles
