ASSESSMENT OF THE STATE OF IMMUNITY IN PATIENTS WITH TUMORS
Keywords:
immunity, orbital tumors, leukocyte formula
Abstract
Cellular immune status provides information on the relative and absolute numbers of cell populations (monocytes, granulocytes and lymphocytes) and subpopulations of lymphocytes in the blood. The human body is equipped with a complex defence mechanism whose primary function is to distinguish foreign antigens from the body's own antigens and initiate an appropriate immune response. Historically, innate immunity differs from adaptive immunity, and these systems work closely together. The immune response is mediated by both cellular components (B- and T-lymphocytes, NK cells, macrophages/monocytes, granulocytes and antigen-presenting cells) and humoral components (antibodies, complement factors, cytokines and other soluble effector molecules). [12,13].
References
1. Wei-Hsin Y., LiA.F, Yu Sh.Y, Chen Y.Y et all. (2020) Evaluate the Differences in CT Features and Serum IgG4 Levels between Lymphoma and Immunoglobulin G4-Related Disease of the Orbit// J Clin Med.-9(8): 2425.Published online 2020 Jul. 29.doi:10.3390/jcm9082425).
2. Gonzalez H., Hagerling C., Werb.Z.(2018) Roles of the immune system in cancer: from tumor initiation to metastatic progression// Genes Dev;32(19-20): 1267-1284. doi: 10.1101/gad.314617.118.
3. Hongbo Zhang, Xuesong Li, Yuntao Li, Baodong Chen, ZhitaoZong, Liang Shen (2020) An Immune-Related Signature for Predicting the Prognosis of Lower-Grade Gliomas// Front Immunol.11: 603341. Published online 2020 Dec 8. doi: 10.3389/fimmu.2020.603341
4. GuomingZeng, Libo Jin, Qinsi Ying, Haojie Chen, Murinda Charmaine Thembinkosi, Chunguang Yang, Jinlong Zhao, HaoJi, Sue Lin, RenyiPeng, Maolan Zhang, Da Sun (2020) Regulatory T Cells in Cancer Immunotherapy: Basic Research Outcomes and Clinical Directions// Cancer Manag Res. 12: 10411–10421. Published online 2020 Oct 21. doi: 10.2147/CMAR.S265828
5. Jesús Fuentes-Antrás, Kissy Guevara-Hoyer, MarionaBaliu-Piqué, et all.,(2020) Adoptive Cell Therapy in Breast Cancer: A Current Perspective of Next-Generation Medicine Front Oncol. 10: 605633. Published online 2020 Oct 27. doi: 10.3389/fonc.2020.605633
6. ZiyadullaevSh, Elmamatov ,Raximov N.(2020) Cytogenetic and immunological alterations of recurrent bladder cancer // European Journal of Molecular & Clinical Medicine ISSN 2515-8260 Volume 7, Issue 2.
7. Saidkulov B., Abduraxmonov J, Rahimov N.(2020) Recurrent ovarian cancer: mechanisms of development of peritoneal malignant ascites. European Journal of Molecular & Clinical Medicine ISSN 2515-8260 Volume 7, Issue 2,
8. Rahimov N., Shakhanova Sh. , Raupov F (2020) Development of new approaches in treatment of metastatic renal cell carcinoma// Journal of research in health science Volume 5-6 issue. 4 pp. 82-95 ISSN 2523-1251 (Online) ISSN 2523-1243 (Print) journal DOI 10.37057/2523-1251 SJIF 2020: 6.224 IFS 2020 4.085 Israel, Yashresh
9. MavlyanovF.Sh. MuhammadievH.KhShukurov F.M. KamolovS.Zh.(2020) Laparoscopy in the complex treatment of severe acute pancreatitis European jornal of Molecular & Clinical Medicine. Volume 07.P.3003-3007.
10. NevinInce, Ertuğrul Güçlü, Mehmet Ali, SungurOğuz Karabay (2020), Evaluation of neutrophil to lymphocyte ratio, platelet to lymphocyte ratio, and lymphocyte to monocyte ratio in patients with cellulitis// Revista da Associação Médica BrasileiraPrint version ISSN 0104-4230 On-line version ISSN 1806-9282 Rev. Assoc. Med. Bras. vol.66 no.8 São Paulo Aug. Epub Sep 11, 2020 https://doi.org/10.1590/1806-9282.66.8.1077
11. Bobdey S., BalasubramaniamG.,PrabhashankarM., AanchalJ. (2017) Role of Monocyte Count and Neutrophil-to- Lymphocyte Ratio in Survival of Oral Cancer Patients// International Archives of OtorhinolaryngologyPrintversionISSN1809-9777On-lineversionISSN 1809-4864 Int. Arch. Otorhinolaryngol.vol.21no.1São PauloJan./Mar.2017 https://doi.org/10.1055/s-0036-1587318
12. Ilkhomovna, K. M., Eriyigitovich, I. S., &Kadyrovich, K. N. (2020). Morphological Features OfMicrovascular Tissue Of The Brain At Hemorrhagic Stroke. The American Journal of Medical Sciences and Pharmaceutical Research, 2(10), 53-59. https://doi.org/10.37547/TAJMSPR/Volume02Issue10-08
13. Shomurodov. K.E. Features of cytokine balance in gingival fluid at odontogenicphlegmon of maxillofacial area. // Doctor-aspirant 2010.-42 Vol.-No.5.1.-P.187-192;
14. Hussain SP, Aguilar F, Amstad P, Cerutti P. (1994). Oxy-radical induced mutagenesis of hotspot codons 248 and 249 of the human p53 gene. Oncogene 9(8):2277-2281.
15. Saidkulov B., Abduraxmonov J, Rahimov N.(2020) Recurrent ovarian cancer: mechanisms of development of peritoneal malignant ascites. European Journal of Molecular & Clinical Medicine ISSN 2515-8260 Volume 7, Issue
16. Rahimov N., Shakhanova Sh. , Raupov F (2020) Development of new approaches in treatment of metastatic renal cell carcinoma// Journal of research in health science Volume 5-6 issue. 4 pp. 82-95 ISSN 2523-1251 (Online) ISSN 2523-1243 (Print) journal DOI 10.37057/2523-1251 SJIF 2020: 6.224 IFS 2020 4.085 Israel, Yashresh
17. Sasaki A, Kai S, Endo Y, et al (2007). Prognostic value of preoperative peripheral blood monocyte count in patients with colorectal liver metastasis after liver resection. J Gastrointest Surg.-vol. 11(5): 596-602.
18. Hornychova H, Melichar B, TomsovaM, Mergancova J, Urminska H, Ryska A. (2008) Tumor-infiltrating lymphocytes predict response to neoadjuvant chemotherapy in patients with breast carcinoma. Cancer Invest.- vol. 26(10):1024-1031
19. Koh YW, Kang HJ, Park C, et al (2012). The ratio of the absolute lymphocyte count to the absolute monocyte count is associated with prognosis in Hodgkin's lymphoma: correlation with tumor-associated macrophages. Oncologist. Vol. 17(6):871-880
20. Bishara S, GriffinM, Cargill A, et al. (2008). Pre-treatment white blood cell subtypes as prognostic indicators in ovarian cancer. Eur J ObstetGynecolReprod Biol. Vol 38(1):71-75
21. Motomura T, Shirabe K, Mano Y, et al (2013). Neutrophil-lymphocyte ratio reflects hepatocellular carcinoma recurrence after liver transplantation via inflammatory microenvironment. J Hepatol vol. 58(1):58-64
22. Schaider H, Oka M, Bogenrieder T, et al(2003). Differential response of primary and metastatic melanomas to neutrophils attracted by IL-8. Int J Cancer. Vol. 103(3):335-343
23. Shamamian P, Schwartz JD, Pocock BJ, et al (2001). Activation of progelatinase A (MMP-2) by neutrophil elastase, cathepsin G, and proteinase-3: a role for inflammatory cells in tumor invasion and angiogenesis. J CellPhysiolvol.189(2): 197-206,
2. Gonzalez H., Hagerling C., Werb.Z.(2018) Roles of the immune system in cancer: from tumor initiation to metastatic progression// Genes Dev;32(19-20): 1267-1284. doi: 10.1101/gad.314617.118.
3. Hongbo Zhang, Xuesong Li, Yuntao Li, Baodong Chen, ZhitaoZong, Liang Shen (2020) An Immune-Related Signature for Predicting the Prognosis of Lower-Grade Gliomas// Front Immunol.11: 603341. Published online 2020 Dec 8. doi: 10.3389/fimmu.2020.603341
4. GuomingZeng, Libo Jin, Qinsi Ying, Haojie Chen, Murinda Charmaine Thembinkosi, Chunguang Yang, Jinlong Zhao, HaoJi, Sue Lin, RenyiPeng, Maolan Zhang, Da Sun (2020) Regulatory T Cells in Cancer Immunotherapy: Basic Research Outcomes and Clinical Directions// Cancer Manag Res. 12: 10411–10421. Published online 2020 Oct 21. doi: 10.2147/CMAR.S265828
5. Jesús Fuentes-Antrás, Kissy Guevara-Hoyer, MarionaBaliu-Piqué, et all.,(2020) Adoptive Cell Therapy in Breast Cancer: A Current Perspective of Next-Generation Medicine Front Oncol. 10: 605633. Published online 2020 Oct 27. doi: 10.3389/fonc.2020.605633
6. ZiyadullaevSh, Elmamatov ,Raximov N.(2020) Cytogenetic and immunological alterations of recurrent bladder cancer // European Journal of Molecular & Clinical Medicine ISSN 2515-8260 Volume 7, Issue 2.
7. Saidkulov B., Abduraxmonov J, Rahimov N.(2020) Recurrent ovarian cancer: mechanisms of development of peritoneal malignant ascites. European Journal of Molecular & Clinical Medicine ISSN 2515-8260 Volume 7, Issue 2,
8. Rahimov N., Shakhanova Sh. , Raupov F (2020) Development of new approaches in treatment of metastatic renal cell carcinoma// Journal of research in health science Volume 5-6 issue. 4 pp. 82-95 ISSN 2523-1251 (Online) ISSN 2523-1243 (Print) journal DOI 10.37057/2523-1251 SJIF 2020: 6.224 IFS 2020 4.085 Israel, Yashresh
9. MavlyanovF.Sh. MuhammadievH.KhShukurov F.M. KamolovS.Zh.(2020) Laparoscopy in the complex treatment of severe acute pancreatitis European jornal of Molecular & Clinical Medicine. Volume 07.P.3003-3007.
10. NevinInce, Ertuğrul Güçlü, Mehmet Ali, SungurOğuz Karabay (2020), Evaluation of neutrophil to lymphocyte ratio, platelet to lymphocyte ratio, and lymphocyte to monocyte ratio in patients with cellulitis// Revista da Associação Médica BrasileiraPrint version ISSN 0104-4230 On-line version ISSN 1806-9282 Rev. Assoc. Med. Bras. vol.66 no.8 São Paulo Aug. Epub Sep 11, 2020 https://doi.org/10.1590/1806-9282.66.8.1077
11. Bobdey S., BalasubramaniamG.,PrabhashankarM., AanchalJ. (2017) Role of Monocyte Count and Neutrophil-to- Lymphocyte Ratio in Survival of Oral Cancer Patients// International Archives of OtorhinolaryngologyPrintversionISSN1809-9777On-lineversionISSN 1809-4864 Int. Arch. Otorhinolaryngol.vol.21no.1São PauloJan./Mar.2017 https://doi.org/10.1055/s-0036-1587318
12. Ilkhomovna, K. M., Eriyigitovich, I. S., &Kadyrovich, K. N. (2020). Morphological Features OfMicrovascular Tissue Of The Brain At Hemorrhagic Stroke. The American Journal of Medical Sciences and Pharmaceutical Research, 2(10), 53-59. https://doi.org/10.37547/TAJMSPR/Volume02Issue10-08
13. Shomurodov. K.E. Features of cytokine balance in gingival fluid at odontogenicphlegmon of maxillofacial area. // Doctor-aspirant 2010.-42 Vol.-No.5.1.-P.187-192;
14. Hussain SP, Aguilar F, Amstad P, Cerutti P. (1994). Oxy-radical induced mutagenesis of hotspot codons 248 and 249 of the human p53 gene. Oncogene 9(8):2277-2281.
15. Saidkulov B., Abduraxmonov J, Rahimov N.(2020) Recurrent ovarian cancer: mechanisms of development of peritoneal malignant ascites. European Journal of Molecular & Clinical Medicine ISSN 2515-8260 Volume 7, Issue
16. Rahimov N., Shakhanova Sh. , Raupov F (2020) Development of new approaches in treatment of metastatic renal cell carcinoma// Journal of research in health science Volume 5-6 issue. 4 pp. 82-95 ISSN 2523-1251 (Online) ISSN 2523-1243 (Print) journal DOI 10.37057/2523-1251 SJIF 2020: 6.224 IFS 2020 4.085 Israel, Yashresh
17. Sasaki A, Kai S, Endo Y, et al (2007). Prognostic value of preoperative peripheral blood monocyte count in patients with colorectal liver metastasis after liver resection. J Gastrointest Surg.-vol. 11(5): 596-602.
18. Hornychova H, Melichar B, TomsovaM, Mergancova J, Urminska H, Ryska A. (2008) Tumor-infiltrating lymphocytes predict response to neoadjuvant chemotherapy in patients with breast carcinoma. Cancer Invest.- vol. 26(10):1024-1031
19. Koh YW, Kang HJ, Park C, et al (2012). The ratio of the absolute lymphocyte count to the absolute monocyte count is associated with prognosis in Hodgkin's lymphoma: correlation with tumor-associated macrophages. Oncologist. Vol. 17(6):871-880
20. Bishara S, GriffinM, Cargill A, et al. (2008). Pre-treatment white blood cell subtypes as prognostic indicators in ovarian cancer. Eur J ObstetGynecolReprod Biol. Vol 38(1):71-75
21. Motomura T, Shirabe K, Mano Y, et al (2013). Neutrophil-lymphocyte ratio reflects hepatocellular carcinoma recurrence after liver transplantation via inflammatory microenvironment. J Hepatol vol. 58(1):58-64
22. Schaider H, Oka M, Bogenrieder T, et al(2003). Differential response of primary and metastatic melanomas to neutrophils attracted by IL-8. Int J Cancer. Vol. 103(3):335-343
23. Shamamian P, Schwartz JD, Pocock BJ, et al (2001). Activation of progelatinase A (MMP-2) by neutrophil elastase, cathepsin G, and proteinase-3: a role for inflammatory cells in tumor invasion and angiogenesis. J CellPhysiolvol.189(2): 197-206,
Published
2021-06-12
How to Cite
Babayev, S. A., Bekturdiev, S. S., Rakhimov, N. M., Jalalova, D. Z., Yusupova, D. Z., & Shakhanova, S. S. (2021). ASSESSMENT OF THE STATE OF IMMUNITY IN PATIENTS WITH TUMORS. Central Asian Journal of Medical and Natural Science, 2(3), 218-225. https://doi.org/10.17605/cajmns.v2i3.204
Issue
Section
Articles
